| 张顺芝1 孙吉1 刘丽华1 陈磊2 陈小平3△.DDAH2 启动子区-1150 C/A多态性与中国汉族人群冠心病
的遗传易感性研究[J].现代生物医学进展英文版,2014,14(5):854-857. |
| DDAH2 启动子区-1150 C/A多态性与中国汉族人群冠心病
的遗传易感性研究 |
| Functional Variant in DDAH2 Contributes to the Susceptibility of CoronaryHeart Disease in a Chinese Population |
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| DOI： |
| 中文关键词: 冠心病 DDAH2 ADMA 多态性 |
| 英文关键词: Coronary artery disease DDAH2 ADMA Polymorphisms |
| 基金项目: |
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| 中文摘要: |
| 摘要目的：研究DDAH2 启动子区-1150 C/A rs805304多态性与中国汉族人群冠心病之间的相关性。方法：应用限制性片段长度
多态性聚合酶链反应（PCR-RFLP）的分析方法，对381 例冠心病患者和629 例健康人群中DDAH2 基因A-1150C rs805304 多态
进行基因分型。结果：病例组和对照组A-1150C rs805304 位点基因型分布均符合Hardy-Wenberg平衡；两组间A-1150C位点基因
型间无显著性的差异（P=0.34）；病例组和对照组A-1150C 位点的等位频率分布也无显著的差别，但是在冠心病病例中，A 等位频
率有低于C 等位频率的趋势（P=0.069）。结论：DDAH2 启动子区-1150 C/A rs805304 多态性与中国汉族人群冠心病的发病不相
关。 |
| 英文摘要: |
| ABSTRACT Objective:To investigate the association of DDAH2 promoter -1150 C/A rs805304 polymorphisms with coronary
heart disease susceptibility in a Chinese Han population by a case-control study.Methods: Polymerase chain reaction-restriction fragment
length polymorphism (PCR-RFLP) was used to genotype the SNP. We performed a case-control analysis including a total of 381cases
and 629 healthy controls. Results:Genotype distribution of the DDAH2 rs805304 polymorphism in both groups were in Hardy-Weinberg
equilibrium. Our pooled result indicated that there is no significant difference in the genotype distribution between the CAD cases and
controls (P=0.34). However, comparing withA allele frequency, the C allele frequency have a lower tendency in cases of coronary heart
disease(P=0.069). Conclusion:the polymorphism(rs805304) of DDAH2 is not associated with the CAD. |
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