| 温大蔚1 王吉波2△ 赵磊2 张婷1 陈智新1.系统性红斑狼疮并发低T3 综合征的影响因素分析[J].现代生物医学进展英文版,2014,14(5):826-829. |
| 系统性红斑狼疮并发低T3 综合征的影响因素分析 |
| Analysis of the Factors Influencing Systemic Lupus ErythematosusCombined with Low Triiodothyronine Syndrome* |
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| DOI： |
| 中文关键词: 系统性红斑狼疮 低T3综合征 疾病活动性 相关性 |
| 英文关键词: Syetemic lupus erythematosus Low triiodothyronine syndrome Disease activity Relativity |
| 基金项目:国家高技术研究发展计划“863 计划”（012AA02A513） |
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| 中文摘要: |
| 摘要目的：探讨系统性红斑狼疮并发低T3综合征的影响因素。方法：选择2102 年6 月~2013 年6 月于我科住院的SLE 女性患
者60 例，其中伴有低T3 综合征的30 例（排除具有原发性甲状腺疾病的病例），甲状腺功能正常的30 例，分析和比较伴有低T3
综合征的SLE患者与甲状腺功能正常的SLE 患者入院时的血常规、C反应蛋白、血沉、肝功能、肾功能、补体C3、补体C4、24 小
时尿蛋白等实验室指标和临床特征，并通过单因素和多因素Logistic 回归分析探讨系统性红斑狼疮并发低T3 综合征的影响因
素。结果：伴有低T3 综合征的SLE 患者SLEDAI 积分、红细胞计数、血红蛋白、血小板、补体C3、白蛋白、谷丙转氨酶、尿素、24 小
时尿蛋白定量与甲状腺功能正常的SLE患者比较均有统计学差异(P<0.05)；Logistic回归分析显示SLEDAI积分(OR=2.194，1.045~4.606，
P=0.038)、血红蛋白(OR=0.719，0.518~0.998，P=0.049)、谷丙转氨酶(OR=2.417，1.071~5.457，P=0.034)、白蛋白(OR=0.
313，0.105~0.934，P=0.037)是系统性红斑狼疮并发低T3 综合征的影响因素。结论：SLEDAI积分和谷丙转氨酶水平是系统性红斑
狼疮并发低T3 综合征的危险性因素，而血红蛋白和白蛋白水平是其保护性因素。 |
| 英文摘要: |
| ABSTRACT Objective:To investigate the factors influencing systemic lupus erythematosus (SLE) with low triiodothyronine (T3)
syndrome. Methods:30 SLE patients with low T3 syndrome, and 30 SLE patients with normal thyroid function were recruited.
Laboratory data including blood routine, C-reactive protein (CRP), erythrocyte sedimentation rate (ESR), liver function, renal function,
serum complement C3, serum complement C4, Urine protein quantification in 24 hours and clinical presentations were collected, and
SLEDAI scores were assessed. The data were analyzed by single and multiple factors Logistic regression analysis. Results:There were
significant differences on SLEDAI scores, red blood cell count, hemoglobin level, platelet count, serum complement C3 level, serum
albumin level, serum glutamate pyruvate transaminase level, urea level, urine protein quantification in 24 hours between the two groups
(P<0.05). SLEDAI scores (OR=2.194, 1.045~4.606, P=0.038), hemoglobin level (OR=0.719, 0.518~0.998, P=0.049), serum glutamate
pyruvate transaminase level(OR=2.417, 1.071~5.457, P=0.034), serumalbumin level(OR=0.313, 0.105~0.934, P=0.037) were considered
as the factors impacting SLE with low T3 syndrome. Conclusion:SLEDAI scores and serum glutamate pyruvate transaminase level are
the risk factors, while hemoglobin and serumalbumin level are the protective factors for SLE combined with low T3 syndrome. |
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