| 李伟 胡海霞 熊正文 苏红 黄勇 李宏伟 张华东 牛晓东.Fascin 蛋白在软骨肉瘤中的表达及其临床意义[J].现代生物医学进展英文版,2014,14(4):772-775. |
| Fascin 蛋白在软骨肉瘤中的表达及其临床意义 |
| Expression of Fascin and its Clinical Significancein Chondrosarcoma |
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| DOI： |
| 中文关键词: Fascin 蛋白 软骨肉瘤 软骨瘤 |
| 英文关键词: Fascin protein Chondrosarcoma Chondroma |
| 基金项目: |
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| 中文摘要: |
| 目的：分析Fascin 蛋白在软骨肉瘤组织中的表达及其与软骨肉瘤临床病理因素的关系。方法：应用免疫组化EnlivionTM 法
分别检测和比较70 例软骨肉瘤和20 例软骨瘤中Fascin 蛋白的表达情况。结果：(1) Fascin 在软骨肉瘤组和软骨瘤组中的阳性表
达率分别为64.29%和5.00%，两组相比差异有统计学意义(X2= 21.88，P=0.00)；(2)Fascin 蛋白的表达与患者的年龄、性别无显著相
关性(X2= 0.37，P=0.54；X2=0.29，P=0.59)；Fascin 蛋白在肺转移组中的表达为76.32%，显著高于无肺转移组(50.00%)，两组相比差
异有统计学意义(X2=5.24，P=0.02)；Fascin 蛋白在间叶性软骨肉瘤、透明细胞软骨肉瘤的中表达分别与普通型软骨肉瘤相比，无统
计学意义(P>0.05)，但去分化软骨肉瘤与普通型软骨肉瘤相比，有统计学意义(P<0.05)；Fascin 在普通型软骨肉瘤的Ⅰ-Ⅲ级中的阳
性表达率分别为11.11%、61.90%、75.00%，三者之间的差异有统计学意义(P<0.05)。结论：Fascin 参与了软骨肉瘤恶变的过程，其高
表达与软骨肉瘤的分化和转移有关。 |
| 英文摘要: |
| Objective:To analyze the expression of fascin protein in chondrosarcoma and relationship with clinicopathological
factors.Methods:The expression of fascin was detected by immunohistochemisty (Enlivion TM) in 70 cases of chondrosarcoma and 20
cases of chondroma.Results:① The expression rate of fascin protein in chondrosarcoma and chondroma were respectively 64.29% and
5.00%, which was significantly higher in chondrosarcoma (X2= 21.88, P<0.00); ②The expression of fascin protein was not significantly
related to age or gender (X2= 0.37, P=0.54; X2=0.29, P=0.59); the expression rate of fascin was 76.32% in the chondrosarcoma with
pulmonary metastasis, which was higher than that in the chondrosarcoma without pulmonary metastasis (50.00%)(X2=5.24, P=0.02); no
significant difference of fascin expression was found between conventional chondrosarcoma and mesenchymal chondrosarcoma or clear
cell chondrosarcoma(P>0.05), but there was statistical difference between dedifferentiated chondrosarcoma and conventional chondrosarcoma
(P<0.05). The expression of fascin in gradeⅠ-Ⅲ of conventional chondrosarcoma were respectively11.11%, 61.90%, 75.00%, and
there was statistical difference among them (P<0.05).Conclusion:Fascin took part in the process of canceration of chondrosarcoma and
was related to the matastasis and differentiation of chondrosarcoma. |
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