| 杨锋 李小飞 吴同 杨三虎 黄立军 卢强 张志培 姜涛.MACC1 蛋白在食管癌中的表达及其临床意义[J].现代生物医学进展英文版,2014,14(4):765-767. |
| MACC1 蛋白在食管癌中的表达及其临床意义 |
| Expression of MACC1 in Esophageal Cancerand its Clinic Significance |
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| DOI： |
| 中文关键词: 食管癌 MACC1 预后 免疫组织化学 |
| 英文关键词: Esophageal cancer MACC1 Prognosis Immunohistochemistry |
| 基金项目:陕西省自然科学基金项目（2009 JM4003-4） |
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| 中文摘要: |
| 目的：探讨结肠癌转移相关基因1（metastasis-associated in colon cancer-1, MACC1）在食管癌组织中的表达及其临床意义。方
法：采用免疫组化EnVinsion 法检测MACC1蛋白在88 例食管癌组织中的表达，统计学分析MACC1 蛋白在不同病理分级、TNM
分期中表达的差异性。结果：免疫组化结果显示MACC1 蛋白的阳性表达主要位于胞浆中。MACC1蛋白在食管癌组织中的总阳
性率为88.64%；在I、II、III 级食管癌组织中的阳性率分别为14.29%、93.65%、100%，经Kruskal-Wallis H检验差异性非常显著
（P=0.0000）；在I、IIa、IIb、III 期食管癌中的阳性率分别是16.67%、89.47%、100%、100%，经Kruskal-Wallis H检验差异性非常显著
（P=0.0000）。结论：MACC1 蛋白在食管癌中呈过度表达，其表达与病理分级、TNM 分期相关，提示MACC1 可能在食管癌的发
生、发展中起重要作用。MACC1蛋白可能成为检测食管癌的发病及判断预后的生物学指标之一。 |
| 英文摘要: |
| Objective:To investigate the expression of MACC1 in esophageal cancer and analyze its clinical significance.Methods:The expression of MACC1 protein in 88 samples of esophageal cancer tissues was detected with immunohistochemical
method-EnVision method; the differences of the protein expression among different pathological grades and TNMstages were statistically
analyzed.Results:The positive expression of MACC1 protein was mainly located in the cytoplasm indicated by immunohistochemical
method. The total positive rate of MACC1 protein in esophageal cancer was 88.64%; the positive expression rates of pathological
gradingI, II, III in esophageal cancer tissues were 14.29% , 93.65% , 100% respectively with extremely significant difference
（Kruskal-Wallis H test, P=0.0000）; the positive expression rates of TNM stageI, IIa, IIb, IIIesophageal cancer tissues were 16.67%,
89.47%, 100%, 100% respectively with extremely significant difference （Kruskal-Wallis H test, P=0.0000）.Conclusion:MACC1
protein is overexpressed in esophageal cancer and its expression rate is related with pathological grading and TNMstage, which suggests
MACC1 might play an important role in the development of esophageal cancer. MACC1 protein may be one of biological indicators for
diagnosis and prognosis of esophageal cancer. |
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