| 廖桂华 王建 周建国 吴文凤 胡猛.安立泽联合胰岛素治疗单独胰岛素降糖欠佳的高龄
2 型糖尿病患者临床观察[J].现代生物医学进展英文版,2014,14(4):735-738. |
| 安立泽联合胰岛素治疗单独胰岛素降糖欠佳的高龄
2 型糖尿病患者临床观察 |
| The Clinical Observation of An Li ze Combined with Insulin Therapy forElderly Type 2 Diabetes Patients with Poor HypoglycemicEffects of Insulin Alone |
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| DOI： |
| 中文关键词: 安立泽 胰岛素 高龄2 型糖尿病患者 |
| 英文关键词: An Li Ze Insulin Elderly patients with type 2 diabetes |
| 基金项目: |
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| 中文摘要: |
| 目的：观察安立泽应用于单独胰岛素治疗血糖控制欠佳的高龄2 型糖尿病患者的疗效及安全性。方法：200 例高龄2型糖尿
病胰岛素降糖欠佳的患者（空腹血糖控制在7.8-13.9mmol/L范围内），随机分成对照组和治疗组，对照组采用胰岛素加安慰剂治
疗80 例；治疗组120 例，分为A、B、C三组，每组40 例，A、B、C三组分别在继续应用胰岛素治疗的基础上加服安立泽4mg/d、
5mg/d、6mg/d，疗程三个月。观测治疗组和对照组治疗前后FPG 及PPG、HbA1C、BMI 和胰岛素用量的改变及治疗的安全性。结
果：对照组和治疗组治疗前的各指标无明显差异（P＞0.05）；A、B、C三组在治疗后1 个月和3 个月FPG、PPG、HbA1C均有明显的
下降（P＜0.05，P＜0.01），而对照组治疗前后FIG、PPG、HbA1C 略有下降，差异不明显（P＞0.05）；A、B、C 三组胰岛素的用量及体
重指数较治疗前均略有下降，三组间无显著性差异；对照组和治疗组的不良反应发生率无显著差异。结论：对高龄2 型糖尿病单
用胰岛素治疗血糖控制欠佳的患者，加用安立泽治疗，可使糖尿病相关指标得以良好的控制，减少糖尿病患者每日胰岛素用量，
临床毒副作用较小。 |
| 英文摘要: |
| Objective:To observe the efficacy and safety of An Lize combined with insulin therapy for elderly type 2 diabetes
patients with poor hypoglycemic effects of insulin alone.Methods:200 cases of elderly type 2 diabetic patients with poor insulin
hypoglycemic (fasting blood glucose control in 7.8-13.9mmol/L range) were randomly divided into control and treatment groups. 80
cases in Control group were treated with insulin plus placebo therapy, treatment group of 120 patients, divided into A, B, C three groups,
each group 40 cases, A, B, C three groups were treated with continued application of insulin therapy, additionally serving An Lize 4
mg/d, 5 mg/d, 6 mg/d, three-month course of treatment. FPGand PPG, HbA1C, BMI and insulin dosage changes and safety of the treatment
of the two groups before and after treatment were observed.Results:The two groups before treatment showed no significant difference (P>
0.05), after treatment in a month, and 3 months, the FPG, PPGand HbA1C of A, B,C three groups were significantly decreased (P <0.05, P
<0.01), while the control group before and after treatment FIG, PPG, HbA1C decreased slightly, which had no significant difference (P>
0.05); A, B, C three groups of insulin dosage and body mass index decreased slightly compared with before treatment, the three groups
showed no significant difference; the incidence of adverse reactions of control group and the treatment group had no significant difference.Conclusion:To those elderly type 2 diabetes patients, who cannot simply use insulin to control blood sugar, plusing An Lize treatment can
control of diabetes related indicators, reduce diabetes daily insulin dosage, and produce small clinical side effects. |
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