| 慕明涛 霍满鹏 张静 刘俊俊 蒲力群.石油作业习惯性流产女性细胞遗传毒性研究[J].现代生物医学进展英文版,2014,14(4):709-711. |
| 石油作业习惯性流产女性细胞遗传毒性研究 |
| Study on Genetic Toxicity of Habitual Abortion Womenin PetroleumOperations |
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| DOI： |
| 中文关键词: 习惯性流产 姐妹染色单体互换 DNA 损伤 |
| 英文关键词: Habitual abortions Sister chromatid exchange(SCE) DNA damage |
| 基金项目:延安大学自然科学研究计划项目（YD2011-04） |
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| 中文摘要: |
| 目的：研究石油作业环境对女性习惯性流产的遗传毒性。方法：随机选择习惯性流产的石油作业女性38人和正常的育龄女
性20 人，检测其外周血淋巴细胞姐妹染色单体互换，记数SCE 发生率。结果：观察组的外周血淋巴细胞SCE 发生率为8.81±
0.35，明显高于对照组（P<0.05）。结论：SCE 的发生可作为石油作业习惯性流产女性染色体结构稳定性的检测指标。石油作业环
境对女性生育具有遗传毒性。 |
| 英文摘要: |
| Objective:To Analyze of Genetic Toxicity in peripheral blood lymphocytes among habitual abortion women in the
petroleum operations.Methods:38 women with habitual abortion and 20 normal women with childbearing age were selected randomly
as observation group and control group respectively. The peripheral blood lymphocytes from them were cultivated and detected by SCE
test method, and the frequency of them was counted.Results:The frequency of SCE was 8.81± 0.35, and its frequency in observation
group was higher than that in control group (P <0.05).Conclusion:The incidence of SCE can be used as the detective index of
chromosome's structural stability of women and genetic toxicity, and is shown in female fertility with habitual abortions who are exposed
to the environment in petroleumoperations. |
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