| 曹风华 吴正福 陈鹏 陈金妹 李莹 张汉园.急性脑梗死患者血清同型半胱氨酸、D- 二聚体和神经元特异性
烯醇化酶水平的变化及其临床意义[J].现代生物医学进展英文版,2014,14(3):542-544. |
| 急性脑梗死患者血清同型半胱氨酸、D- 二聚体和神经元特异性
烯醇化酶水平的变化及其临床意义 |
| Changes of SerumHomocysteic Acid, D-Dimer and Neurone SpecificEnolase Levels in Acute Cerebral Infarction and Their Clinical Significances |
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| DOI： |
| 中文关键词: 同型半胱氨酸 D- 二聚体 神经元特异性烯醇化酶 急性脑梗死 |
| 英文关键词: Homocysteic acid D-Dimer Neurone specific enolase Acute Cerebral Infarction |
| 基金项目: |
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| 中文摘要: |
| 目的：探讨急性脑梗死（acute cerebral infarction，ACI）患者血清同型半胱氨酸（homocysteine，Hcy）、D- 二聚体（d-dimer，DD）
和神经元特异性烯醇化酶（neuronspecific enolase，NSE）水平的变化及其临床意义，为ACI的诊治、预防和病情监测提供更多的实
验依据。方法：选择我院神经内科2010 年1月～2012 年7 月收治的急性脑梗死患者82 例，及同期50 例健康体检人群作为正常
对照组，观察和比较不同病灶及不同神经功能缺损程度患者的血清Hcy、DD和NSE 水平，同时对急性脑梗死患者急性期和恢复
期血中Hcy、DD、NSE 进行分析。结果：①急性脑梗死组Hcy、DD和NSE含量均显著高于正常对照组（P<0.01），急性脑梗死患者
急性期血清Hcy、DD和NSE 水平显著高于恢复期（P<0.01），但恢复期与对照组之间无显著性差异（P>0.05）。②根据病灶大小，急
性脑梗死各组之间血中Hcy、DD和NSE 含量亦存在显著性差异（P<0.05）。③根据神经功能缺损程度，脑梗死各组之间血中Hcy、
DD和NSE 含量亦存在显著性差异（P<0.05）。结论：Hcy、DD 和NSE 与ACI 的发生、发展密切相关，Hcy、DD 和NSE的检测对
ACI的诊断、治疗和预后均有重要意义。 |
| 英文摘要: |
| Objective:To investigate the changes of serumhomocysteic acid (Hcy), D-Dimer (DD) and neurone specific enolase
(NSE) levels in patients with Acute Cerebral Infarction(ACI) as well as their clinical signifiances and provide references for the diagnosis,
treatment, prevention and monitoring of ACI.Methods:82 cases of patients with acute cerebral infarction admitted in the department of
Neurology from January 2010 to July 2012 were selected as the ACI group and 50 healthy persons at the same time were chosen as the
control group. The serum Hcy, DD and NSE levels in the patients of different lesions and different degree of neurological deficits were
observed and compared. The levels of Hcy, DD and NSE in acute and convalescent stage of patients with ACI were also analyzed.Results:① The serumHcy, DD and NSE levels were significantly increased in the ACI group than those in the healthy control (P<0.01),
which was also significantly higher in the acute stage than those in the convalescent stage of ACI (P<0.01). But no significant difference
was observed between the convalescent stage and the healthy control (P>0.05). ②According to the size of the lesion, there were significant
differences in the levels of Hcy, DD and NSE between different group of ACI (P<0.05). ③ According to the degree of neurological
deficits, the levels of Hcy,DD and NSE had the significant differences between different group of ACI (P<0.05).Conclusion:The
levels of Hcy, DD and NSE were closely related to the occurrence and development of ACI. The detection of Hcy, DD and NSE had
important clinical significance on the diagnosis, treatment and prevention of ACI. |
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