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段新辉王蓉徐超李晓军申静王宏.脑梗死患者内脂素和基质金属蛋白酶-9 与颈动脉粥样硬化斑块易损性的关系[J].现代生物医学进展英文版,2014,14(3):500-502.

脑梗死患者内脂素和基质金属蛋白酶-9 与颈动脉粥样硬化斑块易损性的关系

The Relationship of SerumVisfatin and MMP-9 with the Vulnerability ofCarotid Atherosclerotic Plaque in Ischemic Cerebrovascular Disease

DOI：

中文关键词: 内脂素基质金属蛋白酶-9 脑梗死颈动脉粥样硬化易损性

英文关键词: Visfatin Matrix metalloproteinase-9 Brain infarction Atherosclerosis Vulnerability

基金项目:

Author Name	Affiliation
DUAN Xin-hui, WANG Rong, XU Chao, LI Xiao-jun, SHEN Jing, WANG Hong	石河子大学医学院第一附属医院神经内科石河子大学医学院第一附属医院彩超室

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中文摘要:

目的：探讨血清内脂素（Visfatin）及基质金属蛋白酶-9（MMP-9）水平与脑梗死患者颈动脉粥样硬化斑块稳定性的关系和血清visfatin 和MMP-9 的相关性。方法：选择脑梗死患者70 例，根据颈动脉粥样硬化斑块性质分为易损性斑块组(n=43)和非易损性斑块组(n=27)，选取健康体检者30 例作为对照组。测定血清Visfatin 和MMP-9 水平，并对二者间关系进行相关分析。结果：脑梗死伴颈动脉硬化组血清Visfatin、MMP-9 水平高于正常对照组(P＜0.01)；易损性斑块组血清Visfatin 和MMP-9 水平高于非易损性斑块组，差异有统计学意义（P＜0.017）。外周血中的Visfatin水平与MMP-9 呈正相关关系（r=0.643，P=0.000）。结论：在脑梗死患者中，血清Visfatin和MMP-9 参与了颈动脉粥样硬化的病理生理过程，Visfatin 和MMP-9升高可能与颈动脉粥样硬化斑块不稳定性的形成相关，Visfatin 可通过调控MMP-9 的分泌和活性从而改变斑块的易损性。

英文摘要:

Objective:To explore the relationship of Visfatin and MMP-9 with the vulnerability of carotid atherosclerotic plaque and the correlation of serum Visfatin and MMP-9.Methods:According to the carotid atherosclerosis plaque vulnerability, 70 patients with cerebral infarction were divided into vulnerable plaque group (n=43) and unvulnerable plaque group (n=27). Thirty healthy subjects were selected as controls (control group). The levels of serum Visfatin and MMP-9 were examined, and analyse the correlation between them.Results:The level of Visfatin and MMP-9 in the Cerebral infarction associated with carotid atherosclerosis group was significantly higher than that in control group (P＜0.01). The level of Visfatin and MMP-9 in the vulnerable plaque group was higher than that in the unvulnerable plaque group and control group (P＜0.017). A positive correlation was observed between the expression of Visfatin and MMP-9 in vitro (r=0.643, P=0.000).Conclusion:The serumVisfatin and MMP-9 participated in the pathophysiological process of carotid atherosclerosis in cerebral infarction patients, it may be correlation high levels of Visfatin and MMP-9 with the formation of caotid atheroscleotic plaque instability, Visfatin may be regulate MMP-9 secretion and activity, which changes plaques vulnerability.

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