| 佟丹 朱莉 刘磊 林楠 肖巍.Bcl-2 和COX-2 在宫颈鳞癌中的表达及其临床意义[J].现代生物医学进展英文版,2014,14(3):486-489. |
| Bcl-2 和COX-2 在宫颈鳞癌中的表达及其临床意义 |
| The Expression and Clinical Significance of Bcl-2 and COX-2 inCervical Squamous Cell Cancer |
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| DOI： |
| 中文关键词: Bcl-2 COX-2 宫颈鳞癌 表达 临床意义 |
| 英文关键词: Bcl-2 COX-2 Cervical squamous cell cancer Expression Clinical significance |
| 基金项目: |
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| 中文摘要: |
| 目的：观察Bcl-2 和COX-2 在正常宫颈和宫颈鳞癌中的表达情况，并探讨其与宫颈鳞癌发生发展的关系。方法：应用免疫组
织化学S-P法检测40 例宫颈鳞癌组织、10 例正常宫颈组织中Bcl-2 和COX-2 的表达情况。结果：(1)Bcl-2 在正常宫颈组织和宫颈
鳞癌组织中的阳性表达率分别为30.0%、72.5 %(P<0.05)，而COX-2在正常宫颈组织和宫颈鳞癌组织中的阳性表达率分别为0.0 %、
60.0 %(P<0.05)。(2)在宫颈鳞癌中，Bcl-2 的表达与宫颈鳞癌的病理分级、临床分期以及淋巴结转移无关(P>0.05)，而COX-2 的表达
与宫颈鳞癌的病理分级及淋巴转移有关(P<0.05)，与临床分期无关(P>0.05)。(3)Spearman 等级相关性分析显示宫颈鳞癌组织中
Bcl-2 和COX-2的表达呈正相关(r=0.517，P<0.01)。结论：Bcl-2 和COX-2 在宫颈鳞癌中的表达升高并呈显著正相关，且COX-2的
表达与宫颈鳞癌的淋巴转移有关，二者在宫颈癌的发生发展中可能起重要作用，有可能作为评估宫颈鳞癌淋巴结转移的参考指
标。 |
| 英文摘要: |
| Objective:To detect the expression of Bcl-2 and COX-2 in cervical squamous cell cancer and explore the clinical
significance of Bcl-2 and COX-2 in the development of cervical squamous cell cancer.Methods:The expression of Bcl-2 and COX-2 in
40 cases of cervical squamous cell cancer and 10 cases of normal cervical tissue were detected by immunohistochemical SP method.Results:(1)The positive expression rates of Bcl-2 in normal cervical tissue and cervical squamous cell cancer were 30.0 %and 72.5%,
respectively (P<0.05).The positive expression rates of COX-2 in normal cervical tissue and cervical squamous cell cancer were 0.0%and
60.0%, respectively( P<0.05). (2)The expression of Bcl-2 in cervical squamous cell cancer was not related with the histological grade, the
clinical stage and the lymph node metastasis (P>0.05), while the expression of COX-2 in cervical squamous cell cancer was related with
the histological grade and the lymph node metastasis(P<0.05), but not related to the clinical stage(P＞0.05). (3)The expression of Bcl-2
was positively correlated with the expression of COX-2 (r ＝0.517, P<0.05).Conclusion:The upregulation of Bcl-2 and COX-2
expression which were positively related were involved in the development of cervical squamous cell cancer, they may be used as
indicators of the prognosis of cervical squamous cell cancer. |
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