| 马娟 张奉超 王云骥 陈超 彭蓓.瑞芬太尼、芬太尼对小儿扁桃体切除术中应激反应和苏醒期躁动的影响[J].现代生物医学进展英文版,2014,14(3):468-470. |
| 瑞芬太尼、芬太尼对小儿扁桃体切除术中应激反应和苏醒期躁动的影响 |
| The Influence of Remifentanil and Fentanyl on Stress Response andRestlessness in Pediatric Tonsillectomy |
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| DOI： |
| 中文关键词: 瑞芬太尼 芬太尼 小儿扁桃体切除术 应激反应 苏醒期躁动 |
| 英文关键词: Remifentanil Fentanyl Pediatric Tonsillectomy Stress Response Restlessness |
| 基金项目: |
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| 中文摘要: |
| 目的：探讨瑞芬太尼、芬太尼对小儿扁桃体切除术中应激反应以及苏醒期躁动的影响。方法：选择2012 年1 月至2012 年
12 月期间择期行扁桃体切除手术的患儿80 例为研究对象，将其分随机为瑞芬太尼组（40 例）和芬太尼组（40 例），比较两组患者
不同时间应激反应指标（ACTH、COR、IL-6）、苏醒时间、躁动评分、躁动发生率以及RamSay 镇静评分，探讨两种麻醉药物的临床
应用价值。结果：两组术前ACTH、COR、IL-6的基础应激指标比较，差别无统计学意义(P>0. 05)。瑞芬太尼组及芬太尼组术毕该三
项指标较术前升高，术后1d 较术毕有回落，差别有统计学意义（P<0.05）；瑞芬太尼组术毕﹑术后 1d 的各项指标均远远低于芬太尼
组，差别有统计学意义（P<0.05）。瑞芬太尼组苏醒时间明显少于芬太尼组，躁动评分明显低于芬太尼组，躁动发生率明显低于芬太
尼组，RamSay镇静评分明显高于芬太尼组，差别有统计学意义（P<0.05）。结论：瑞芬太尼引起的应激反应明显弱于芬太尼组，且其
苏醒期躁动情况明显优于芬太尼组，值得进一步推广应用。 |
| 英文摘要: |
| Objective:To investigate the influence of remifentanil and fentanyl on stress response and restlessness in pediatric
tonsillectomy.Methods:80 cases of children with tonsillectomy from January to December in 2012 were selected in the study, and all of
themwere randomly divided into two groups: the remifentanil group ( 40 cases ) and the fentanyl group ( 40 cases ). The different time
stress reaction Index (ACTH, COR, IL-6), recovery time, agitation score, the incidence of agitation and RamSay sedation score were
compared between two groups. Effects of the clinical value between two narcotic drugs were investigated.Results:The differences of
preoperative based stress indicators of ACTH, COR, IL-6 between two groups were not statistically significant (P>0.05). The levels of
three indicators increased in the two group after surgery, and decrease in 1d after the surgery, the differences were statistically significant
(P <0.05). Each indicator after surgery and in 1d after surgery in the remifentanil group were lower than those in the fentanyl group. The
recovery time in the remifentanil group was significantly less than that in the fentanyl group. The incidence of agitation score and
restlessness in the remifentanil group were significantly lower than those in the fentanyl group, RamSay sedation score in the remifentanil
group was significantly higher than that in the fentanyl group, the differences were statistically significant (P<0.05).Conclusion:The
stress response of remifentanil is significantly weaker than fentanyl, its restlessness is better than fentanyl, thus it is worthy of further
promotion. |
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