| 李学庆 全应军 孙晓红 陈湧湘 叶桃.Caveolin-1 和nm23在乳腺癌组织中的表达及意义[J].现代生物医学进展英文版,2014,14(3):437-440. |
| Caveolin-1 和nm23在乳腺癌组织中的表达及意义 |
| Expression and Clinical Meaning of Caveolin-1 and nm23 in Breast Cancer |
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| DOI： |
| 中文关键词: 乳腺癌 Caveolin-1 nm23 免疫组化法 |
| 英文关键词: Breast cancer Caveolin-1 nm23 Immunohistochemistry technology |
| 基金项目:上海市闵行区科委课题（2010MHZ022） |
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| 中文摘要: |
| 目的：探讨Caveolin-1 和nm23 在乳腺癌组织中的表达及意义。方法：选取于我院就诊的172 例乳腺癌患者的乳腺组织和40
例乳腺增生患者的正常乳腺组织，采用免疫组化技术检测标本中Caveolin-1和nm23的表达，并分析其与患者的临床病理之间的
关系。结果：免疫组化结果显示Caveolin-1 和nm23 在乳腺癌组织中的表达均低于正常乳腺组织（P<0.05），且两者的表达呈正相
关（r= 0.609，P<0.05）；其中Caveolin-1 的表达与乳腺癌的临床分期及淋巴结转移有关（P<0.05），nm23 的表达与乳腺癌的临床分
期、组织学类型及淋巴结转移有关（P<0.05）。结论：Caveolin-1 和nm23 的表达可能是乳腺癌发生发展的重要原因，可应用于临床
诊治乳腺癌患者。 |
| 英文摘要: |
| Objective:To explore the expression of Caveolin-1 and nm23 and their clinical meaning in breast cancer.Methods:Choosed the breast tissue in 172 cases of breast cancer who have been treated in our hospital and normal breast tissue in 40 cases of
mammary gland hyperplasia, immunohistochemistry technology was used in test the expression of Caveolin-1 and nm23 in the sample,
analyzed the relationship between the patient and clinical pathology.Results:The result of immunohistochemistry technology showed
that the expression of Caveolin-1 and nm23 in breast cancer tissue was lower than in normal breast tissue(P<0.05), the expression of them
was positive correlated(r=0.609, P<0.05), the expression of Caveolin-1 was related to the clinical stage of breast cancer and the lymphatic
metastasis (P<0.05), the expression of nm23 was related to the clinical stage of breast cancer, the histological type and lymphatic
metastasis (P<0.05).Conclusion:The expression of Caveolin-1 and nm23 maybe is an important reason for the incidence and
development of breast cancer, which could applied to clinical diagnosis and the treatment of breast cancer. |
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