| 李伟1 张华2△ 李伟3 马朋朋4 李双霞3.肺炎衣原体感染与青少年I型糖尿病的相关性研究[J].现代生物医学进展英文版,2014,14(2):309-312. |
| 肺炎衣原体感染与青少年I型糖尿病的相关性研究 |
| Correlational Study on the Chlamydia Pneumonia Infection with AdolescentType1 Diabetes Mellitus |
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| DOI： |
| 中文关键词: 肺炎衣原体 1型糖尿病 青少年 实时定量PCR 糖化血红蛋白 |
| 英文关键词: Chlamydia pneumonia Type 1 diabetes mellitus Adolescent Real time PCR Glycosylated haemoglobin |
| 基金项目: |
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| 中文摘要: |
| 摘要目的：探讨肺炎衣原体感染与青少年I型糖尿病的相关性，为I 型糖尿病的的临床治疗提供参考依据。方法：选择2010 年12
月-2012 年6 月间石家庄地区各医院收治的49 例青少年T1DM 患者为观察组，及同期50 例健康人作为对照组，应用即时指尖
血免疫测定仪分析受试者HbA1c 水平；应用RT-PCR 技术检测血液中Cpn DNA；应用ELISA 方法检测受试者血清中Cpn特异
性抗体水平，对Cpn DNA的检出情况及HbA1c 水平与Cpn DNA和特异性抗体水平的相关性进行统计学分析。结果：观察组
Cpn DNA 的检出率为46.9%，显著高于对照组(P<0.05)；观察组Cpn 抗体阳性率显著高于对照组(P<0.05)，且观察组再次感染或慢
性感染Cpn 的百分率显著高于对照组(P<0.05)；HbA1c 与IgG/IgA 抗体水平显著相关，血糖控制较差(HbA1c>9%)的糖尿病患者
Cpn IgG/IgA 抗体阳性率与血糖控制较好的患者(HbA1c<7%)相比显著升高(P<0.05)。结论：与健康对照相比，青少年T1DM 患者
更容易感染Cpn，且更容易由急性感染状态进展为慢性感染形式，良好的血糖可能降低患者发生与代谢控制有关的慢性并发症。 |
| 英文摘要: |
| ABSTRACT Objective：To evaluate the association between Chlamydia pneumoniae(Cpn) infection and adolescent Type1 Diabetes
Mellitus (T1DM), and provide basis for the clinical treatment of T1DM.Methods： HbA1c was measured by the point-of-care
immunoassay; Cpn DNA was detected by real time PCR; The serum Cpn specific antibody IgA, IgG, IgM were measured by ELISA.
Results: Cpn DNA was performed in 46.9% of the patients with T1DM, this prevalence was higher than that in control group(P<0.05);
Cpn antibody and re-infection or chronic infection rate were higher in observation group than those in the control group (P<0.05); There
was a significant positive correlation between the HbA1c and the IgG/IgA. Cpn IgG/IgA antibody positivity was significantly (P<0.05)
more common in HbA1c>9% patients versus HbA1c<7%patients. Conclusion:Adolescents with T1DM were more likely to show signs
of infection with Cpn, and have an increased risk from an acute Cpn infection to a chronic form. Good glycaemic control may reduce the
chronic complications related to metabolic control. |
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