| 曾柏伦1 彭文鸿2 王瑞娟2 张文娟3 许丽芳3.机械通气与乌司他丁治疗急性呼吸窘迫综合症的疗效观察[J].现代生物医学进展英文版,2014,14(2):286-288. |
| 机械通气与乌司他丁治疗急性呼吸窘迫综合症的疗效观察 |
| Clinical Effect Observation of Mechanical Ventilation Combined withUlinastatin in Treatment of Acute Respiratory Distress Syndrome |
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| DOI： |
| 中文关键词: 机械通气 乌司他丁 急性呼吸窘迫综合症 |
| 英文关键词: Mechanical ventilation Ulinastatin Acute Respiratory Distress Syndrome |
| 基金项目: |
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| 中文摘要: |
| 摘要目的：观察机械通气与乌司他丁治疗急性呼吸窘迫综合症的临床疗效。方法：回顾性分析60 例急性呼吸窘迫综合症患者的
资料，治疗组（30例）采取机械通气与乌司他丁治疗，对照组（30 例）采取机械通气治疗，观察两组的的呼吸频率、PaO2、PaO2 /FiO2、
PCO2、APACHEII评分、胸片变化、VAP 发生率及病死率。结果：治疗组的呼吸频率、PaO2、PaO2/FiO2、PCO2指标均优于对照组（t=6.
39，6.27，24.07，9.82，P<0.05）；治疗组的VAP发生率20.0%明显小于对照组的36.7%(X2 =5.84，P=0.016<0.05)；治疗组的病死率
3.3%明显小于对照组的16.7%(X2= 5.71，P=0.017<0.05)。两组之间的APACHEII评分及胸片变化均有明显差异（t= 7.14，6.33，
P<0.05）。结论：机械通气与乌司他丁治疗急性呼吸窘迫综合症的临床疗效较好，能够较好地改善肺功能，缓解ARDS 患者症状，
提高安全可靠性，控制死亡率。 |
| 英文摘要: |
| ABSTRACT Objective：To observe the clinical effect of mechanical ventilation combined with ulinastatin in treatment of acute
respiratory distress syndrome.Methods： Date of Sixty patients with acute respiratory distress syndrome were retrospectively analyzed,
treatment group (30 cases) were treated using mechanical ventilation combined with ulinastatin; control group (30 cases) were treated
using mechanical ventilation, then the respiratory frequency, PaO2, PaO2/FiO2, PCO2, APACHEII scores, chest radiograph change, VAP
incidence and mortality in the two groups were observed. Results：Respiratory frequency, PaO2, PaO2 /FiO2 and PCO2 in treatment group
were better than those in control group (t=6.39, 6.27, 24.07, 9.82，P<0.05); VAP incidence was 20.0%in treatment group, and was less
than 36.7%in control group ( X2 =5.84, P=0.016<0.05); mortality (3.3%) in treatment group was less than 16.7%in control group (X2=
5.71, P=0.017<0.05). APACHEII scores and chest X-ray changes between the two groups had obvious difference (t=7.14, 6.33, P < 0.05).
Conclusion：The clinical effect of mechanical ventilation combined with ulinastatin in treatment of acute respiratory distress syndrome is
good; the treatment can improve lung function, alleviates the symptoms, improves the safety and reliability and controls the mortality. |
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