| 李三阳1 李怡1 程龙2 王珺1 尹国武1△.自然流产患者绒毛和蜕膜中ZEB1 的差异性表达及意义*[J].现代生物医学进展英文版,2014,14(2):261-264. |
| 自然流产患者绒毛和蜕膜中ZEB1 的差异性表达及意义* |
| Differential Expression of ZEB1 in Patients' Villi and Decidual withSpontaneous Abortion* |
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| DOI： |
| 中文关键词: 自然流产 锌指结合蛋白1 蜕膜 绒毛 |
| 英文关键词: Spontaneous abortion ZEB1 Decidual Villi |
| 基金项目:国家自然科学基金项目（81100440）；陕西省攻关项目（2011K15-02-04） |
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| 中文摘要: |
| 摘要目的：检测锌指结合蛋白（zinc finger E-box-binding protein ，ZEB1）在自然流产患者绒毛和蜕膜组织中的差异性表达。方法：
选取2010 年3 月到2011 年3 月在我院妇产科门诊进行人工流产的患者，分为正常人工流产（对照组50 例）和自然流产（实验组
50 例）两组，两组年龄和孕周间差异无统计学意义（P＞0.05）。用荧光实时定量PCR（qRT-PCR）技术检测在绒毛和蜕膜组织中
ZEB1 mRNA的表达量。结果：自然流产患者绒毛（0.835± 0.047）中ZEB1的表达量低于对照组（1.942± 0.095），自然流产患者蜕
膜（0.65± 0.058）中ZEB1 的表达量低于对照组（1.13± 0.084），差异具有统计学意义(P＜0.05)。结论：绒毛及蜕膜组织中ZEB1 的
异常表达可能参与自然流产的发生发展过程。 |
| 英文摘要: |
| ABSTRACT Objective：To explore the differential expression of ZEB1 in embryos damage patients decidual and villi tissue.Methods：
The woman whoes embryos damage were Select (n=50) as the experimental group, the same period in normal early pregnancy
voluntarily request the abortion of women (n=50) as a control group, respectively, leaving whichever villi and decidual tissue, using a
real-time quantitative PCR (qRT-PCR) of specimens ZEB1 mRNA transcription level analysis. Results：Villus samples, ZEB1mRNA
expression levels in the experimental group（0.835± 0.047）was significantly higher than that in the control group（1.942± 0.095）. in the
decidual specimens, ZEB1 mRNA expression levels of the experimental group（0.65± 0.058）was significantly higher than that in the
control group （1.13 ± 0.084）. Conclusion：The differences in the expression of ZEB1 in decidual and villi may be involved in the
occurrence and development of the embryos damage. |
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