| 王洪波 杨德君 刘岩 王科亮 王晓民.染色体畸形变与膀胱癌发生发展的相关性研究[J].现代生物医学进展英文版,2014,14(1):156-158. |
| 染色体畸形变与膀胱癌发生发展的相关性研究 |
| Correlation of the Chromosomal Abnormalities with the Occurrenceand Development of Bladder Cancer |
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| DOI： |
| 中文关键词: 荧光原位杂交 膀胱肿瘤 染色体 |
| 英文关键词: Fluorescence in situ hybridization Bladder tumors Chromosome |
| 基金项目: |
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| 中文摘要: |
| 目的：通过荧光原位杂交技术(FISH)结合病理分级，探讨染色体畸形变与膀胱癌发生和发展的关系。方法：采用3、7、9、17 号
染色体着丝粒探针和9P16 区带探针对105 例膀胱癌复发患者尿液脱落细胞进行荧光原位杂交，观察膀胱癌复发患者中3、7、9、
17 号染色体的畸形变情况并分析其与患者临床和病理特征之间的关系。结果：105 例膀胱癌复发患者中，3、7、9 和17 号染色体的
非整数倍突变率分别是21.9%、29.5%、12.4%、和36.2%，与患者的性别、年龄无显著相关性(P>0.05)。仅7 号染色体畸变与膀胱癌
的病理分级具有显著相关性(P<0.05)。结论：7 号染色体畸形变与复发膀胱癌的病理分级显著相关。 |
| 英文摘要: |
| Objective: To explore the correlation of chromosome abnormalities changes with bladder cancer occurrence and development
by fluorescence in situ hybridization (FISH) combined with pathological grade. Methods: 3,7,9,17 chromosome centromeric
probes and 9P16 zone probe 105 cases of bladder cancer recurrence in patients with urine exfoliated cells by fluorescence in situ
hybridization, the 3,7,9,17 chromosome abnormal change in the patients with bladder cancer recurrence and the relationship between the
clinical and pathological features were analyzed.Results: In 105 cases of recurrent bladder cancer, the non-integer multiple mutation
rates of 3,7,9 and 17 chromosome was 21.9%, 29.5%, 12.4%, and 36.2%, respectively, which had no correlation with the patient's
gender, age (P>0.05). Only the aberrations of chromosome 7 was significantly correlated with the pathological grade of recurrent bladder
cancer (P<0.05). Conclusion: The aberrations of chromosome 7 was significantly correlated with the pathological grade of recurrent
bladder cancer. |
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