| 吴云娟 严孝岭 张晓军 吕成银 张缪佳.评价抗SSA、抗SSB 和抗a- 胞衬蛋白抗体在诊断干燥
综合征中的价值[J].现代生物医学进展英文版,2014,14(1):130-131. |
| 评价抗SSA、抗SSB 和抗a- 胞衬蛋白抗体在诊断干燥
综合征中的价值 |
| Diagnostic Value of Anti-SSA , Anti-SSB and Anti-alpha-fodrinAntibody in Sjogren's Syndrome |
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| DOI： |
| 中文关键词: SS 抗a- 胞衬蛋白抗体 抗SSA抗体 抗SSB 抗体 |
| 英文关键词: Anti-SSB Anti-alpha-fodrin Anti-SSA Anti-SSB |
| 基金项目: |
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| 中文摘要: |
| 目的：评价SSA、SSB 和胞衬蛋白在诊断干燥综合征(SS)中的价值。方法：用酶联免疫吸附试验（ELISA）检测47 例确诊为SS
患者、20 例其它自身免疫病(类风湿关节炎7 例、SLE6 例、自身免疫性肌炎7 例)和20 例体检健康者血清抗SSA、SSB 和a- 胞衬
蛋白抗体，分析三种自身抗体阳性率。结果：抗SSA抗体、抗SSB 抗体和抗a-胞衬蛋白抗体敏感性分别为76.6%、38.3%、42.6%；
特异性分别为72.5%、95.0%、82.5%；三种抗体联合检测后敏感性为89.4%，特异性50.0%。结论：抗a- 胞衬蛋白抗体与抗SSA、
SSB 抗体联合检测时可提高阳性率，对症状不典型的SS 患者诊断有一定的补充意义。 |
| 英文摘要: |
| Objective: To assess the diagnostic value of anti-SSA, anti-SSB and anti-alpha-fodrin antibody in Sjogren's Syndrome
(SS) . Methods: Serumsamples were collected from47 patients with SS，20 patients with other autoimmune diseases(including 7 cases of
rheumatoid arthritis, 13 cases of systemic lupus erythematosus）and 20 normal human controls. Enzyme-linked immunosorbent assay
(ELISA) and immunoblotting were performed to test anti-SSA, anti-SSB and anti-alpha-fodrin antibody in these serum samples.Results: The sensitivities of anti-SSA, anti-SSB and anti-alpha-fodrin antibody in SS were 76.6%, 38.3%acsnnd 42.6%, respectively, and the
specificities were 72.5%, 95.0% and 82.5%, respectively. The combination of anti-SSA, anti-SSB and anti-alpha-fodrin antibody had a
higher sensitivity(89.4%), but it had a lower sensitivity(50.0%). Conclusion: The combination of anti-SSA, anti-SSB and anti-alpha-fodrin
antibody can significantly improve the sensitivity to diagnose SS and offer clinical benefits for diagnosis of SS whose symptoms are not
typical. |
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