| 党雅梅 陈城 车团结 郭应芳.PBRM1 和P21 蛋白在子宫内膜癌的表达及意义[J].现代生物医学进展英文版,2014,14(1):117-120. |
| PBRM1 和P21 蛋白在子宫内膜癌的表达及意义 |
| Analysis on the Correlation between PBRM1 and P21with Endometrial Cancer |
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| DOI： |
| 中文关键词: 子宫内膜癌 PBRM1 P21 免疫组织化学 |
| 英文关键词: Endometrial cancer PBRM1 P21 Immunohistochemistry |
| 基金项目:甘肃省科学计划项目（096RJZA071）；兰州市科学计划项目（2010-1-143）；甘肃省科学计划项目（1113JHTA003） |
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| 中文摘要: |
| 目的：探讨PBRM1 和P21 蛋白在子宫内膜癌中的表达和临床意义。方法：应用免疫组化方法对105 例子宫内膜癌组织进
行PBRM1和P21 蛋白检测。结果：子宫内膜癌中PBRM1 和P21 的阳性表达率分别为62.86%和80%；癌旁组织PBRM1 和P21
阳性表达率分别为45.71%和34.2%，子宫内膜癌组织表达高于癌旁组织（P＜0.05）；PBRM1 和P53 阳性表达与组织学类型、浸润
深度、淋巴结转移、组织学分级、临床TNM分期相关（P＜0.05），与患者年龄无关（P＞0.05）。PBRM1 和P21 的表达呈正相关（P＜
0.05）。结论：PBRM1 和P21 表达水平与子宫内膜癌组织的病理分级和临床分期的增高而增高，对其进行监测对子宫内膜癌的诊
断、治疗及预后有指导意义。 |
| 英文摘要: |
| Objective:To study the expression of PBRM1 and P21 in endometrial cancer and its clinical significance．
The protein of PBRM1 and P21was examined in 105 cases of endometrial cance immunohistochemistry. Methods: The protein of PBRM1 and P21was examined in 105 cases of endometrial cance immunohistochemistry. Results: The positive expression
rate of PBRM1and P21 in the carcinoma and the normal tissues of endometrial cancer was 62.86% and 80%, respectively, which had
significant difference （P＜0.05）. While the positive expression rate of P53 was 45.71% and 34.2%, respectively, which significant
difference（P＜0.05）. The expressive of both PBRM1 and P53 were related to different tissue types, the depth of invasion, lymph node
metastasis, histology stage, the clinical stage（P＜0.05）, no correlation existed with age of endometrial cancer.（P＞0.05）.Conclusion:The expression level of PBRM1 and P21 increased markedly with the clinical stage or clinical grade of endometrial cancer. The mutation
of gene and hormonal imbalalance may play an important role in endomefriun Oncogenesis and metaetasis of carcinoma of endometrium. |
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