| 叶云飞杨倞孟岩△ 孙永健徐胜.三维适形放疗技术的治疗原发性肝癌的影响因素分析[J].现代生物医学进展英文版,2012,12(27):5347-5349. |
| 三维适形放疗技术的治疗原发性肝癌的影响因素分析 |
| Image Factors of the Three-Dimensional Conformal Radiotherapy |
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| DOI： |
| 中文关键词: 三维适形放疗技术 原发性肝癌 影响因素 |
| 英文关键词: Three-dimensional conformal radiotherapy technology Primary liver cancer Radiation dose Effect |
| 基金项目: |
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| 中文摘要: |
| 目的：探讨影响三维适形放疗(3-Dimensional conformal radiotherapy,3DCRT)治疗原发性肝癌的影响因素。方法：收集2008
年1 月到2010 年12 月间58 例我院原发性肝癌病人，先通过CT 扫描定位勾画靶区，经实时验证参数后实施适形放射治疗。观察
疗效。并运用Cox 回归模型对肿瘤大小、肿瘤分期、肝功能和甲胎蛋白(AFP)水平和照射剂量因素进行分析。结果：完全缓解(CR)
13 例，部分缓解(PR)35 例，总有效(CR+PR)率为82.76%，1、2、3 年生存率分别为69.5%、43.10%、27.57%。肿瘤大小、肿瘤分期、甲
胎蛋白水平和照射剂量可影响3DCRT 效果（P 小于0.05），肝功能对3DCRT 效果（P 小于0.05）。结论：肿瘤分期、肝功能和甲胎
蛋白(AFT)水平，分割方式、照射剂量和效应可影响三维适形放疗治疗原发性肝癌的效果。 |
| 英文摘要: |
| Objective: To investigate the impact of three-dimensional conformal radiotherapy (3-Dimensional conformal
radiotherapy with 3DCRT) treatment of primary liver cancer influencing factors. Methods: 58 cases of hospital patients with primary liver
cancer in January 2008 to December 2010, the first CT scan positioning outlined target, the implementation of conformal radiation
therapy after real-time authentication parameters. Effects were observed. And the use of Cox regression model on the tumor size, tumor
stage, liver function and alpha-fetoprotein (AFP) levels and radiation dose factors were analyzed. Results: Complete remission (CR) 13
cases, partial remission (PR), 35 cases, the total effective (CR+PR) rate was 82.76%, 1-, 2-and 3-year survival rates were 69.5%, 43.10%,
27.57%. Tumor size, tumor stage, alpha-fetoprotein levels and radiation dose can affect the the 3DCRT effect (P less than 0.05), liver
function, the the 3DCRT effect (P less than 0.05). Conclusion: Tumor stage, the level of liver function and alpha-fetoprotein (AFT),
partitioned, radiation dose and effects may influence the effect of three-dimensional conformal radiation therapy for primary liver cancer. |
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