| 潘社棉1 孟宏涛2△ 顾勇2 马勇智2 杨爱华2.64 例结肠黑变病回顾性分析[J].现代生物医学进展英文版,2012,12(27):5342-5343. |
| 64 例结肠黑变病回顾性分析 |
| A Retrospective Analysis of 64 Patients with Melanosis Coli |
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| DOI： |
| 中文关键词: 黑变病 结肠息肉 结肠肿瘤 回顾性分析 |
| 英文关键词: Melanosis coli Colon polyp Colon cancer Retrospective analysis |
| 基金项目: |
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| 中文摘要: |
| 目的：探讨分析结肠黑变病(melanosis coli，MC)的致病因素、预后及其与结肠癌、结肠息肉等疾病的关系。方法：回顾性分析
由电子结肠镜检出的64 例MC 患者的临床资料、内镜表现及病理结果。结果：64 例患者中47 例有便秘，服用葸醌类泻药史者54
例。诊断为MCI°24 例(37.5％)，MCⅡ°28 例(43.8％)，MCⅢ°12 例(18.7％)。合并有结肠息肉14 例、痔疮9 例、溃疡性结肠炎2
例、结肠癌1 例。结论：服用泻药、便秘以及相关细胞凋亡是导致MC 发生的重要因素。泻剂主要为蒽醌类，MC 的发病率与性别不
存在相关性，其与结肠癌、结肠息肉和溃疡性结肠炎等的关系需要进一步深入研究，应积极给予早期诊断和治疗。 |
| 英文摘要: |
| Objective: To investigate and analyze the causal factors and prognosis of melanosis coli (MC), and its correlation with
colon cancer, colon polyp and other diseases. Methods: Clinical data, endoscopic manifestation and pathologic results of 64 subjects with
MC was retrospectively analyzed. Results: Among the 64 MC patients, 47 patients have constipation, 54 patients have used laxative
anthraquinone. 24 patients were diagnosed as MCI0 (37.5％), 28 diagnosed as MCⅡ°(43.8％)and 12 diagnosed as MCⅢ° (18.7％).
14 patients were complicated with colon polyp, 9 with piles, 2 with ulcerative colitis, 1 with colon cancer. Conclusion: Laxative usage
(mainly anthraquinone), constipation and related cell apoptosis are important factors leading to MC. No correlation existed between the
incidence of MC and gender. More efforts are needed to clarify its relationship with colon cancer, polyp and ulcerative colitis, and early
diagnosis and treatment are necessary. |
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