| 闫泽兆天欣邢影陈丹何璐璐.替吉奥联合顺铂治疗晚期胃癌临床疗效研究[J].现代生物医学进展英文版,2012,12(27):5324-5326. |
| 替吉奥联合顺铂治疗晚期胃癌临床疗效研究 |
| Curative Effect Analysis of S-1 Combined with Cisplatin in the Treatment ofAdvanced Gastric Cancer |
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| DOI： |
| 中文关键词: 胃肿瘤 替吉奥 卡培他滨 顺铂 治疗结果 |
| 英文关键词: Stomach neoplasms S-1 Capecitabine Cisplatin Treatment outcome |
| 基金项目: |
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| 中文摘要: |
| 目的：研究替吉奥联合顺铂治疗晚期胃癌的疗效和安全性。方法：42 例晚期胃腺癌患者随机分为观察组(21 例)与对照组(21
例)两组，观察组采用替吉奥联合顺铂，对照组采用卡培他滨联合顺铂。结果：两组患者疗效间差异无统计学意义(P>0.05)。两组的
不良反应主要为骨髓抑制、消化道反应和乏力，观察组Ⅲ～Ⅳ度血小板减少发生率显著低于对照组(P<0.05)，Ⅲ ～ Ⅳ度手足综合
征的发生率亦显著低于对照组(P<0.05)。结论：替吉奥联合顺铂治疗晚期胃癌疗效与卡培他滨联合顺铂相当，但其患者耐受性更
好，值得临床进一步研究推广使用。 |
| 英文摘要: |
| Objective: To investigate the safety and efficacy of S-1 combined with cisplatin in the treatment for patients with
advanced gastric cancer. Methods: Forty-two patients with advanced gastric cancer were randomly divided into two groups. Patients in
observation group (n=21) received S-1 and cisplatin; Patients in control group (n=21) received capecitabine and cisplatin. Results: The
efficacy of the two groups showed no statistically significant difference (P>0.05). The main untoward effects were myelosuppression,
gastroenteric reaction and weakness. Observation group showed a lower rate of untoward effects than control group. Observation group
also showed a lower rate of Ⅲ～Ⅳ thrombocytopenia (P<0.05) and hand-foot syndrome (P<0.05) than control group. Conclusions: The
treatment of the two groups were evidently effective, with observation group having better tolerance. The regimen could be clinically
recommended. |
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