| 康英英李波李明霍莹莹李芸兰.前列地尔联合川芎嗪治疗早期糖尿病肾病的疗效观察[J].现代生物医学进展英文版,2012,12(27):5268-5270. |
| 前列地尔联合川芎嗪治疗早期糖尿病肾病的疗效观察 |
| The Effect of Ligustrazine and Alprostadil on the Early Diabetic Nephropathy |
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| DOI： |
| 中文关键词: 前列地尔 川芎嗪 糖尿病肾病 24h 尿蛋白定量 |
| 英文关键词: Alprostadil Ligustrazine Diabetic nephropathy 24h urinary albumin |
| 基金项目: |
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| 中文摘要: |
| 目的：观察前列地尔（凯时）联合川芎嗪注射液（川青）治疗糖尿病肾病的临床疗效,探讨其降低尿蛋白，减轻肾损害的机制。
方法：收集早期2 型糖尿病患者120 例，随机分成川芎嗪组(40 例)、前列地尔组(40 例)和联合治疗组(40 例)。全部病例进行临床观
察2 周,分别比较三组血肌酐(Cr)、尿素氮(BUN)、24 h 尿蛋白定量治疗前后的变化。结果：治疗2 周后,联合治疗组降低24 h 尿蛋
白定量的作用优于川芎嗪组和前列地尔组差异有统计学意义(P<0.05)。前列地尔组和川芎嗪组比较,差异有统计学意义(P<0.05)。
结论：静脉应用前列地尔联合川芎嗪注射液能够降低糖尿病肾病患者尿蛋白,延缓糖尿病肾病的进展, 值得临床推广。 |
| 英文摘要: |
| Objective: Ligustrazine and Alprostadil treatment of the early diabetic nephropathy. Methods: 120 patients with early
type 2 diabetes of hospitalization were collected and randomly divided into 3 groups: Ligustrazine group (40 cases), Alprostadil group(40
cases), combined therapeutic group (40 cases). All cases were observed for 2 weeks. The changes of serum creatinine (Cr), blood urea
nitrogen (BUN), 24 hour urinary albumin before and after the treatment were compared. Results: After treatment for 2 weeks, the
treatment of combined therapeutic group in decreasing 24 h urinary albumin was better than Ligustrazine group and Alprostadil group,the
differences were significant (P<0.05). The differences between Ligustrazine group and Alprostadil group were significant (P<0.05).
Conclusion: The treatment of Alprostadil combined with Irbesartan in early diabetic nephropathy is an effective way. Intravenous
ligustrazine and alprostadil can delay the progression of diabetic nephropathy. It would be valuable to widespread popularization. |
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