| 罗丹1 尹合坤1 李启祥1 邹益友2 阳惠湘2.血浆内皮素及降钙素基因相关肽在颅脑手术患者中的检测分析[J].现代生物医学进展英文版,2012,12(26):5140-5142. |
| 血浆内皮素及降钙素基因相关肽在颅脑手术患者中的检测分析 |
| The Change Regularities of Plasma Endothelin and CalcitoninGene-Related Peptide in Patients with Brain Surgery |
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| DOI： |
| 中文关键词: 颅脑手术 应激 内皮素 降钙素基因相关肽 |
| 英文关键词: Brain surgery Stress Endotheline Calcitonin gene-related peptide |
| 基金项目: |
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| 中文摘要: |
| 目的：观察颅脑手术患者血浆内皮素及降钙素基因相关肽在应激性胃黏膜损伤中的变化规律，探讨在应激状态下胃黏膜损
害的可能机制。方法：监测15 例颅脑手术患者的血浆内皮素及降钙素基因相关肽，并应用放射免疫法分点测定术前及术后血浆
内皮素及降钙素基因相关肽含量。结果：15 例颅脑手术病人手术前后血浆内皮素及降钙素基因相关肽比较有显著差异性（P<
0.05）。结论：内源性内皮素及降钙素基因相关肽可能是应激性胃黏膜损伤的重要致病因子。 |
| 英文摘要: |
| Objective: To observe the change regularities of endothelin and calcitonin gene-related peptide in development of
Stress-induced gastric mucosal injury, to investigate the possible pathogenesis of gastric mucosal injury under stringent state. Methods:
The levels of plasma endothelin and calcitonin gene-related peptide in 15 patients who received brain surgery were measured in different
periods by radioimmunoassay. Results: In group of 15 patients who received brain surgery, the level of plasma endothelin increased and
calcitonin gene-related peptide decreased in postoperative period. There are significant differences of them between preoperative period
and postoperative period（P<0.05）. Conclusion: Endogenous ET and CGRP are important causative factors in development of stress
ulcer. |
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