| 金星1 崔红花2 陶曙红2 尹永芹2△.尼美舒利的临床应用及其不良反应[J].现代生物医学进展英文版,2012,12(25):4995-4997. |
| 尼美舒利的临床应用及其不良反应 |
| Clinical Applications of Nimesulide and its Adverse Reactions |
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| DOI： |
| 中文关键词: 尼美舒利 非类固醇抗感染药物 临床应用 不良反应 |
| 英文关键词: Nimesulide NSAIDs Clinical applications Adverse side reaction |
| 基金项目:广东省建设中医药强省科研课题（2009248） |
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| 中文摘要: |
| 尼美舒利具有强大的抗炎、镇痛和解热作用。临床主要用于急慢性疼痛、关节炎、月经痛、癌症疼痛和解热。其作用机理主要
是通过选择性抑制COX-2 而抑制前列腺素的合成。尼美舒利的不良反应与其他NSAIDs 相似，但对胃肠道副作用较少。本文总结
了尼美舒利的主要临床应用及不良反应。 |
| 英文摘要: |
| Nimesulide has strong anti-inflammatory, analgesic and antipyretic effects. Clinically, it is the principal treatment in
various acute and chronic pain conditions, joint in覲ammation in osteoarthritis, dysmenorrhoea, cancer pain, and anti-pyretic. Its mode of
action in these states is related to the preferential inhibition of the production of cyclo-oxygenase-2 (COX-2). The adverse reaction pro覱le
of nimesulide is like that of other NSAIDs. However, Nimesulide has a relatively low incidence of gastrointestinal (GI) side effects. This
review summarized the principal clinical applications and adverse reaction of nimesulide. |
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