| 刘辰庚王培昌△.microRNA 对淀粉样前体蛋白调控的研究进展[J].现代生物医学进展英文版,2012,12(25):4977-4980. |
| microRNA 对淀粉样前体蛋白调控的研究进展 |
| Development of the Regulation of microRNA on Amyloid Protein Precursor |
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| DOI： |
| 中文关键词: 淀粉样前体蛋白 microRNA β 淀粉样蛋白 调控 |
| 英文关键词: Amyloid protein precursor MicroRNA β amyloid proteins Regulation |
| 基金项目: |
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| 中文摘要: |
| 淀粉样前体蛋白（APP）参与了神经肌肉的信号传导、突触的可塑性及空间学习等生理过程，APP 在阿兹海默病（AD）人脑组
织中高表达，其切割产物β 淀粉样蛋白（Aβ）则在AD 的发生发展中起到重要作用。2011 年4 月，美国阿兹海默病协会将Aβ 的聚
集程度列入了新版AD 诊疗指南中，通过减少APP 的表达或降低其以β 切割方式进行代谢来延缓AD 的进展已成为很多学者的
共识。microRNA (miRNA)是一类内生的、长度约19-24 个核苷酸的小RNA，其在细胞内具有多种重要的调节作用，据推测，miRNA
调控着人类约三分之一的基因。自2008 年首次明确miRNA 对APP 表达存在调控作用之后，miRNA 对APP 的调控和相关机制
的研究以及其对AD 诊断和治疗潜在价值的探索已成为AD 研究领域的热点之一，本文主要就miRNA 对APP 的表达、剪切和切
割的调控及Aβ 对miRNA 的影响做一综述。 |
| 英文摘要: |
| The amyloid protein precursor (APP) mediates the nerve-muscle signal transmission, synaptic plasticity and space
study physiological processes which are high-expressed in the brain of the Alzheimer's disease (AD) patients. The β amyloid protein
(Aβ), one of the cleaved products of APP, plays an important role in AD events. Aβ aggregates degree is listed in the new practice guidelines
of AD by the Alzheimer's association in April 2011. By reducing the expression of APP or inhibiting its β cleaving ways to slow the
progress of AD has become the consensus of many scholars. MicroRNA (miRNA) is a kind of endogenous small RNA, with around
19-24 nucleotide of length, which has many important regulatory roles. It is supposed that miRNA regulates about one-third of the human
gene. Lots of researches focus on the regulative role of miRNA to the APP and its mechanism as well as its value of the diagnosis and
treatment to AD since the evidence was found that miRNA can regulate the expression of APP. In this review, we focus on the role of
miRNA on the expression, splicing and cleaving of the APP as well as the effect of Aβ to the miRNA. |
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