| 张丹丹1 董小黎2 杨黎明1 刘立新1 孟桂霞1.不稳定动脉粥样硬化斑块的研究进展[J].现代生物医学进展英文版,2012,12(25):4961-4963. |
| 不稳定动脉粥样硬化斑块的研究进展 |
| The Research of Unstable Atherosclerotic Plaque |
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| DOI： |
| 中文关键词: 不稳定斑块 组织蛋白酶-S 生长相关基因蛋白-α 内质网应激 |
| 英文关键词: Unstable plaque Cathepsin S GRO-α Endoplasmic reticulum |
| 基金项目:北京市教委基金（KM200710025006） |
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| 中文摘要: |
| 不稳定斑块破裂及继发血栓形成是导致急性心血管事件发生的主要病理基础。不稳定斑块的形成与炎症反应、细胞凋亡等
有密切联系，新近研究表明，组织蛋白酶-S、生长相关基因蛋白-α 和内质网应激在动脉粥样硬化斑块趋向不稳定的过程中发挥
至关重要的作用。本文就相关研究进展进行综述，为深入了解不稳定斑块的形成机制提供依据。 |
| 英文摘要: |
| Unstable atherosclerotic plaque rupture and subsequent thrombosis are the main patho-reason leading to acute cardiovascular
event occur. There is close relationship between inflammatory reaction, apoptosis and unstable plaque formation. Recent studies
show that Cathepsin S, GRO-α and endoplasmic reticulum play important role in the formation of unstable plaque. This article will give a
review on this research, to provide the basis for a thorough understanding of the unstable plaque mechanism. |
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