| 孙娇丽王鹏△.带状疱疹后遗神经痛的动物模型及病理机制研究[J].现代生物医学进展英文版,2012,12(25):4953-4955. |
| 带状疱疹后遗神经痛的动物模型及病理机制研究 |
| The Animal Model and Pathogenesis Research of Postherpetic Neuralgia |
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| DOI： |
| 中文关键词: 带状疱疹 带状疱疹后遗神经痛 动物模型 病理机制 |
| 英文关键词: Shingles zoster Postherpetic neuralgia Animal model Pathogenesis |
| 基金项目: |
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| 中文摘要: |
| 带状疱疹后遗神经痛( postherpetic neuralgia, PHN)是带状疱疹最常见的并发症，其发生率随年龄的增加而增加，并且严重影
响患者的生活质量。目前PHN 的治疗多采用复合用药，但效果不佳。阻碍其治疗发展的关键是对PHN 的发病机制不甚清楚，究其
根本原因是缺乏与临床符合的动物模型。目的：综述带状疱疹病毒感染模型的改良和进展，使PHN 的病理机制得到进一步揭示。
内容：介绍与PHN 相关的水痘- 带状疱疹病毒潜伏感染模型、体外模型及慢性感染模型，综述与PHN 发生发展有关的潜伏机制、
与其他神经病理性痛相似的机制及近年来较为关注的中枢与外周损伤机制。趋向：进一步研究与人类水痘带状疱疹病毒感染更
为相似的动物模型，并随其改良和进展，使发生PHN 的机制得到进一步的阐释。 |
| 英文摘要: |
| PHN (Postherpetic neuralgia, PHN) is the most common complication of shingles zoster, the incidence of which is
increased with age, which affect the quality of patient seriously. At the present, the PHN is often treated with complex medication, but the
affect is not obvious. However, the development of therapies to PHN has been hampered by the unclear of the pathogenesis of PHN, and
further more by the lock of animal models which is coincident with clinical. This review introduced the improvement and further research
of the animal model infected by VZV (varicella zoster virus, VZV), the pathological of PHN will be further revealed. Content: The animal
model of latent infection, in vitro infection and chronic infection associated with PHN are described, in additional, the latent mechanism,
the mechanism similar with the other neuropathic pain and the damage of centrum and periphery which is paid more attention by the
research are also introduced in detail. Trend: With the further research of animal model which is more coincident with clinical, and the
pathological mechanism of PHN will be further revealed with progressing of animal model of PHN. |
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