| 徐忠金谢淑佩林媛媛朱春晖何飞.噬血细胞综合征临床特征与影响预后因素分析[J].现代生物医学进展英文版,2012,12(25):4910-4912. |
| 噬血细胞综合征临床特征与影响预后因素分析 |
| Analysis of the Clinical Characteristics and Factors Affecting Prognosis ofHemophagocytic Syndrome |
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| DOI： |
| 中文关键词: 噬血细胞综合征 危险因素 分析 |
| 英文关键词: Hemophagocytic syndrome Risk factor Analysis |
| 基金项目: |
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| 中文摘要: |
| 目的：探讨噬血细胞综合症的临床特征及影响预后因素，为临床治疗提供依据。方法：选择2006 年1 月~2011 年12 月我院
收治的噬血细胞综合症患儿26 例，回顾分析所有患儿的临床表现、实验室检查、病因及转归等资料。结果：死亡10 例，好转或痊
愈16 例。原发与继发性HPS 转归情况比较，X2=7.825，P＜0.05，差异有统计学意义。两组年龄（t=2.807）、肝肿大（t=2.817）、脾肿大
（t=2.651）、白细胞计数（t=2.580）、血小板（t=2.814）、纤维蛋白原（t=2.984）、乳酸脱氢酶（LDH）（t=2.667）和丙氨酸转氨酶（ALT）
（t=2.514）比较，差异有统计学意义，P＜0.05。结论：儿童噬血细胞综合征病因复杂，临床特征多样，应结合患儿个体特征进行临床
治疗。 |
| 英文摘要: |
| Objective: To analysis the clinical characteristics and impact factors of hemophagocytic syndrome, in order to provide
basis for clinical treatment. Methods: A retrospective analysis of the clinical characteristics, laboratory data, causes and outcomes was
made for 26 patients with hemophagocytic syndrome in our hospital from Jan. 2006 to Dec. 2011. Results: 10 children with hemophagocytic
syndrome were dead, 16 children were on the mend or recovery. The prognosis of primary and secondary HPS was statistical different
significantly(X2=7.825, P＜0.05). The age(t=2.807, P＜0.05), the size of enlargement of liver and spleen(t=2.817 and t=2.651, P＜0.05),
WBC(t=2.580, P＜0.05), blood platelet (t=2.814, P＜0.05), FIB（t=2.984, P＜0.05）, LDH（t=2.667, P＜0.05）and ALT（t=2.514, P＜
0.05）of two groups were statistical different significantly. Conclusion: HPS for children presented complicated causes, various clinical
characteristics and high mortality. HPS should be treated with individual factors for children. |
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