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目的：分析巨幼细胞性贫血脾肿大的超声表现及临床结果的相关性。方法：①选择2008 年至2011 年在哈尔滨医科大学第二临床医院血液内科住院的巨幼细胞性贫血患者239 例。②按贫血程度将患者设为重度贫血组108 例（血红蛋白>30 g/L）；中度贫血组78 例（血红蛋白>60 g/L）；轻度贫血组53 例（血红蛋白>90 g/L）。③超声检查显示脾厚度超过4 cm 或长度超过8 cm，最大长径超过11 cm 以及左肋缘下探及脾，均可判定为脾大。④率的资料比较采用卡方检验，相关性分析采用Pearson 相关。结果：对不同贫血程度的脾大发生率进行比较分析，采用卡方检验（x2=22.873，P<0.01）。贫血程度与脾大进行Pearson 相关性分析（r＝ 0.309，P<0.01）。结论：①巨幼细胞性贫血可导致脾肿大。②脾大与贫血程度有关系。

英文摘要:

Objective: To analyze the correlation between clinical outcome and splenomegaly in megaloblastic anemia patients. Methods: ① 239 patients with megaloblastic anemia were admitted who entered the Department of Hematology, the Second Affiliated Hospital of Harbin Medical University from 2008 to 2011. ② These patients were divided into three groups according to the degree of anemia: 108 patients with severe anemia (hemoglobin>30 g/L), 78 patients with moderate anemia (hemoglobin>60 g/L) and 53 patients with mild anemia (hemoglobin>90 g/L). ③It was judged as splenomegaly that spleen was thicker than 4 cm, or longer than 8 cm, or the major diameter of spleen was more than 11 cm by ultrasonic inspection. Splenomegaly was also decided when it could be touched along the ribs.④Comparative analysis of the rate was made using x2, and relevance analysis was carried out by Pearson's correlation coefficient. Results: x2 was used to compare the different incidence of splenomegaly of patients with different degree of anemia. (x2=22.873, P < 0.01). Pearson's correlation coefficient was used to evaluated the relationship between splenomegaly and degree of anemia. (r=0.309, P < 0.01). Conclusion:①Megaloblastic anemia could contribute to splenomegaly. ②The degree of anemia was involved in splenomegaly.

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