| 郭晓东1 张苧月2 赵景民1 熊璐1 周光德1 赵雨来1.VEGF 和MMP-9 在肝癌病理诊断中的应用价值[J].现代生物医学进展英文版,2012,12(25):4845-4847. |
| VEGF 和MMP-9 在肝癌病理诊断中的应用价值 |
| Application Value of VEGF and MMP-9 in Pathological Diagnosisof Liver Cancer |
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| DOI： |
| 中文关键词: 血管内皮生长因子 基质金属蛋白酶-9 原发性肝癌组织 免疫组化 |
| 英文关键词: VEGF MMP-9 Primary hepatocareinoma Immunohistochemical method |
| 基金项目:国家" 十二五" 科技重大专项课题（2012ZX10002-003） |
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| 中文摘要: |
| 目的：探讨血管内皮生长因子（VEGF）和基质金属蛋白酶-9（MMP-9）在原发性肝癌（PHC）组织中的表达及病理诊断价值。
方法：采用免疫组化法，检测80 例PHC 标本和30 例正常组织中VEGF 和MMP-9 的表达。结果：PHC 组VEGF 和MMP-9 阳性
表达率分别为68.8%、62.5%，均显著高于对照组（23.3%、26.7%），相比较有显著性差异（P<0.05）。肿瘤直径≥5 cm、无包膜和低分
化肿瘤组织中VEGF 和MMP-9 阳性表达均显著高于肿瘤直径<5 cm、包膜完整和高中分化肿瘤组，相比较有显著性差异（P<0.
05）；而VEGF 和MMP-9 阳性表达在不同性别和年龄构成之间、有癌栓组和无癌栓组之间、AFP 阳性组和阴性组之间差异无统计
学意义（P>0.05）。结论：VEGF 和MMP-9 在PHC 组织中呈高表达，VEGF 和MMP-9 可以作为PHC 的预后指标。 |
| 英文摘要: |
| Objective: To study the expression of VEGF and MMP-9 in tissue of primary hepatocareinoma (PHC) and application
value in pathological diagnosis of PHC. Methods: The VEGF and MMP-9 expression from 80 cases of PHC tissues and 30 cases of normal
tissue were detected by immunohistochemical method. Results: The VEGF and MMP-9 positive rate of the PHC group was 68.8%
and 62.5%, and the normal tissue group was 23.3% and 26.7%, respectively, having significant differences (P<0.05). The VEGF positive
rate in tissue of tumor diameter ≥ 5 cm, no capsule and poorly differentiated tumor were significantly higher than the diameter < 5 cm,
encapsulated, high - moderately differentiated tumor (P <0.05). The VEGF positive rate was no significantly different among the different
gender and age, with or without thrombosis, AFP-positive group and negative group (P>0.05). Conclusion: The VEGF and MMP-9 hav
high expression in PHC tissues. The VEGF and MMP-9 can be used as prognostic indicators of PHC. |
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