| 黄胜蓝郑长黎△.与胃癌发生相关MicroRNA 的研究新进展[J].现代生物医学进展英文版,2012,12(24):4777-4779. |
| 与胃癌发生相关MicroRNA 的研究新进展 |
| The Research on the Development of Gastric Cancer-related MicroRNA |
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| DOI： |
| 中文关键词: MicroRNA 胃癌 癌基因 抑癌基因 肿瘤 |
| 英文关键词: MicroRNA Gastric cancer Oncogene Anti-oncogene Tumor |
| 基金项目: |
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| 中文摘要: |
| MicroRNA（微小核糖核酸；miRNA）是一类长约20～25 个核苷酸的非编码的单链RNA 分子。它的表达与个体发育、增殖、
分化以及恶性肿瘤发生密切相关[1,2]。近期研究表明microRNA 具有癌基因和抑癌基因的作用。新研究发现miR-20b, miR-150,
miR-106a, miR-27a, miR107,miR-21,miR-20a 与胃癌的发生过程呈正相关； 而Let-7microRNA, miR-218, miR-101, miR-650,
miR-29，miR-34，miR-451 与胃癌的发生过程呈负相关。本文就胃癌发生相关microRNA 的研究新进展予以综述。 |
| 英文摘要: |
| MicroRNA are endogenous non-coding RNA about 20～25 nucleotide; There are close association between expression
of microRNA and biologic processes including individual development cell apoptosis, proliferation, differentiation diseases (such as
malignant tumor). Recent studies indicate that microRNA can function as both oncogene and anti-oncogent. miR-20b, miR-150,
miR-106a, miR-27a, miR107and miR21, miR-20a have been demonstrated to be positively regulated to the development of the gastric
cancer; Let-7microRNA, miR-218, miR-101, miR-650, miR-29, miR-34 and miR-451 have been demonstrated to be negatively regulated
to the development of the gastric cancer. This article reviewed the research advancement about microRNA in gastric cancer. |
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