| 于燕张锐卫焱星彭珊珊任利容△.妊娠期糖尿病孕妇血清脂质运载蛋白-2 水平变化及临床意义初探[J].现代生物医学进展英文版,2012,12(24):4735-4737. |
| 妊娠期糖尿病孕妇血清脂质运载蛋白-2 水平变化及临床意义初探 |
| Change of Serum Lipocalin-2 Level in Pregnant Women with GestationalDiabetes Mellitus and its Clinical Significance |
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| DOI： |
| 中文关键词: 脂质运载蛋白-2 妊娠期糖尿病 炎症反应 C- 反应蛋白 |
| 英文关键词: Lipid carrier protein-2 GDM Inflammation CRP |
| 基金项目:深圳市宝安区科技局资助项目（2010531） |
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| 中文摘要: |
| 目的：了解妊娠期糖尿病（GDM）孕妇血清脂质运载蛋白-2(LCN-2)水平的变化及临床意义，探讨LCN-2 的水平变化是否与
炎症反应相关。方法：测定30 例GDM 孕妇及30 例正常孕晚期孕妇血清LCN-2 水平、空腹血糖（FPG）、糖化血红蛋白（HbA1c）、
空腹胰岛素（Fins）水平，计算胰岛素抵抗指数，检测白细胞计数（WBC）、中性粒细胞百分比（N）、及血清C 反应蛋白（CRP）水平，
并对两组结果进行统计对比分析。结果：（1）GDM 组孕妇血清LCN-2 水平为（70.69±6.85）ng/mL，高于正常孕妇血清LCN-2 水平
（67.02±6.58）ng/mL，差异有统计学意义（P<0.05)。（2）GDM 组孕妇FPG、HbA1c、Fins、HOMA-IR 水平分别为[（5.35±0.57）
mmol/L、（5.66±0.60）%、（9.38±1.32）mIU/L、（2.24±0.45）]，明显高于正常孕妇血清水平[（5.00±0.26）mmol/L、（4.72±0.51）%，
（8.26±0.76）mIU/L、（1.83±0.23）]，差异有统计学意义（P<0.01)。（3）GDM 组孕妇血液WBC、N 水平分别为（8.77±1.75）×109/L、
（72.07±3.91）%，正常孕妇血清水平为（8.49±1.26）×109/L、（73.18±3.87）%，差异无统计学意义（P>0.05)。GDM 组孕妇CRP 水平
为（5.21±0.91）g/L，正常孕妇血清水平CRP 为（3.71±1.27）g/L，差异有统计学意义（P<0.05)。结论：GDM 孕妇血清LCN-2 水平升
高，可能参与了GDM 的病理过程，但血清LCN-2 水平与临床常用的炎症反应标志物并不相关。 |
| 英文摘要: |
| Objective: To explore change of serum lipocalin-2(LCN-2) level in pregnant women with gestational diabetes mellitus
(GDM) and its potential clinical significance, as well as the association between LCN-2 level and inflammation. Methods: The levels of
serum LCN-2, fasting plasma glucose (FPG), glycosylated hemoglobin (HbA1c), Fasting insulin level (Fins), homeostasis model assessment
ratio (HOMA-IR), leucocyte count, neutrophil percentage and C-reaction protein were tested in 30 GDM women and 30 normal
controls. Results: (1)The level of serum LCN-2 in GDM group(70.69±6.85 ng/mL) was significantly higher than that in controls(67.02±
6.58 ng/mL) (P<0.05). (2)The levels of FPG, HbA1C, Fins, HOMA-IR in the GDM group [(5.35±0.57) mmol/L; (5.66±0.60)%;
(9.38±1.32) mIU/L; (2.24±0.45)] were significantly higher than those in controls[(5.00±0.26) mmol/L; (4.72±0.51)%; (8.26±0.76)
mIU/L; (1.83±0.23)] (P<0.01). (3)The leucocyte count and the neutrophil percentage between these two groups were not significantly
different[(8.77±1.75)×109/L vs (72.07±3.91)%; (8.49±1.26)×109/L vs (73.18±3.87)%] (P>0.05). The CRP level in GDM group
(5.21±0.91 g/L) was significantly higher than that in controls (3.71±1.27 g/L) (P<0.05). Conclusions: The higher level of LCN-2 indicates
its potential role in the pathomechanism of GDM and this hypothesis warrants further research, since our results didn't find association
between LCN-2 level and inflammatory marker clinically commonly used. |
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