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目的：探讨对终末期肾病患者行甲状旁腺切除对颈动脉钙化的影响。方法：选择我院2009 年10 月至2010 年12 月收治的 20 例继发性甲状旁腺功能亢进的终末期肾病患者，行甲状旁腺切除术，对患者术前、术后进行颈动脉彩超检查颈动脉钙化情况，并将患者术前、术后的血钙、血磷、钙磷乘积、PTH、C 反应蛋白、血红蛋白、白蛋白等指标进行比较。结果：与术前比较，术后患者颈动脉钙化斑块有明显减少，血钙、血磷、钙磷乘积、PTH、C 反应蛋白均明显降低，差异性有显著（P<0.05）；血红蛋白较术前明显升高（P<0.05）。结论：切除甲状旁腺（PTX）能安全有效的降低甲状旁腺素水平、改善钙磷代谢紊乱，并控制颈动脉钙化的进展。

英文摘要:

Objective: To investigate the impact of parathyroidectomy on carotid calcification for patients with end stage renal disease (ESRD), and to evaluate the effect of parathyroidectomy on carotid calcification, calcium and phosphate abnormality of end-stage renal disease patients. Methods: 20 parathyroid patients with ESRD of hyperparathyroidism from October, 2010 to October, 2011 in our hospital were excised and enrolled in this study. Carotid calcification was recorded before and after PTX. Meanwhile, the serum calcium, phosphorus, calcium-phosphate product, PTH, C-reactive protein, hemoglobin and albumin were compared before and after the surgery. Results: Compared with pre-operation, the serum calcium, phosphorus, calcium-phosphate product, PTH, C-reactive protein were significantly decreased in post-operation (P<0.05), and hemoglobin concentration was higher in post-operation than pre-operation (P<0.05). Conclusions: The removal of parathyroid glands (PTX) could rapidly and securely reduce the PTH, serum calcium levels and calcium- phosphate product. It could prevent progression of vascular calcification and relieve the syndrome of patients with ESRD.

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