| 刘爱群1 邓国平1 刘建2 陈森林2 刘志红2.G3BP 在结肠癌中表达的临床病理学研究[J].现代生物医学进展英文版,2012,12(24):4708-4710. |
| G3BP 在结肠癌中表达的临床病理学研究 |
| A Clinicopathological Study on G3BP Expression in Colon Carcinoma |
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| DOI： |
| 中文关键词: 结肠癌 G3BP 免疫组织化学 预后 转移 |
| 英文关键词: Colon cancer G3BP Immunohistochemistry Prognosis Metastasis |
| 基金项目: |
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| 中文摘要: |
| 目的：探讨G3BP（Ras-GTPase-activiting protein SH3 domain binding protein）在结肠癌组织中的表达及其临床病理意义。方
法：用免疫组织化学技术检测50 例结肠癌组织中G3BP 的表达，并分析其与患者临床病理指标的关系及其对预后的影响。结果：
G3BP 在结肠癌中阳性表达率为72%（36/50），G3BP 的阳性表达率与肿瘤分化程度、淋巴结转移、病变浸润层次及TNM 分期有
关。而与年龄、性别、肿瘤大小无关（P＞0.05）。G3BP 高表达组患者的生存时间明显短于低表达组。结论：G3BP 表达与结肠癌的
侵袭和转移相关，可能是结肠癌的预后差的指标。 |
| 英文摘要: |
| Objective: To investigate the expression of G3BP （Ras-GTPase-activiting protein SH3 domain binding protein）in
colon cancer (CC ) and its clinical pathological significance. Methods: The expression of G3BP was investigated by immunohistochemical
staining in each 50 pathologically verified CC, and the relation to clinical pathological index was involved. Results: The G3BP positive
expression rate in CC was 72%（36/50）. The expression of G3BP was associated with tumor differentiation, lymph node metastasis, invasion
depth and TNM stage, but not with age, gender, tumor diameter (P>0.05). The G3BP high expression group had a significantly shorter
median survival time than the low expression group patients. Conclusion: G3BP is closely related to invasion and metastasis of CC,
and may be an index for poor prognosis. |
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