王曙辰李辉夏世斌韩立强赵忠尧石岭.HIF-1α 在垂体腺瘤中的表达及与垂体腺瘤侵袭性的关系[J].现代生物医学进展英文版,2012,12(24):4704-4707. |
HIF-1α 在垂体腺瘤中的表达及与垂体腺瘤侵袭性的关系 |
The Expression of HIF-1α in Pituitary Adenomas and Relationship withInvasion of Pituitary Adenomas |
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DOI: |
中文关键词: 垂体腺瘤 缺氧诱导因子 侵袭性 |
英文关键词: Pituitary adenoma Hypoxia inducible factor 1α Invasive |
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中文摘要: |
目的:研究缺氧诱导因子-1α(HIF-1α)在人垂体腺瘤中的表达,对HIF-1α 蛋白表达与肿瘤分级进行相关性分析,探讨其表达
水平与垂体腺瘤侵袭性的关系。方法:集影像学检查、内分泌学检查及病理诊断的垂体腺瘤60 例,分为侵袭组和非侵袭组,其中
侵袭组36 例,非侵袭组24 例;对照组正常脑组织5 例。免疫组织化学技术检测HIF-1α 蛋白的表达,结合临床资料进行统计学分
析。分析垂体腺瘤HIF-1α 蛋白的表达水平并与对照组进行比较,比较侵袭组和非侵袭组垂体腺瘤之间HIF-1α 蛋白表达水平的
差异。结果:HIF-1α 蛋白在垂体腺瘤中的表达明显高于对照组,二者比较,x2
0.05,1 =12.392,P<0.001,有显著性差异;侵袭组HIF-1α
蛋白的表达较非侵袭组显著增高,二者比较,x2
0.05,1 =24.658,P < 0.001,有显著性差异。结论:HIF-1α 是垂体腺瘤侵袭过程中的重要
调控因子,与垂体腺瘤的大小、分级以及侵袭性密切相关,其作用机制有待进一步研究,其表达程度可用作垂体腺瘤预后的评估
指标,为垂体腺瘤术后的复发以及相应的辅助治疗提供判断依据。有可能为人们靶向肿瘤缺氧来开发新药物提供新的作用靶点。 |
英文摘要: |
Objective: To study the protein expressions of hypoxia inducible factor 1α(HIF-1α) in pituitary adenomas, and the correlation
of protein expression HIF-1α with the grade and volume of pituitary adenomas, and probe the relationship between proteins and
invasion of pituitary adenomas. Methods: Sixty surgical samples of pituitary adenomas were diagnosed by examine of biology and endocrinology,
divided into invasive and non-invasive pituitary adenomas groups and in 5 normal sham patients. Analysis of pituitary adenoma
HIF-1 α protein expression level and compared with the control group, more invasive group and the attack group between pituitary
adenoma HIF-1 α protein expression level of the differences. Results: The Protein expression of HIF-1α in Pituitary adenomas group
were significantly higher than sham group (x2
0.05,1 =12.392,P<0.001); HIF-1α in invasive Pituitary adenomas group were significantly
higher than non-invasive Pituitary adenomas group (x2
0.05,1=24.658, P<0.001). Conclusion: Hypoxia- inducible - 1 alpha may be an important
regulatory factors in pituitary adenoma' invasive, and the size and grading with the invasive closely related, the mechanism of its action
research further. |
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