| 刘红崔建英岳华陆晨△ 刘颖赵红娟.探讨尿视黄醇结合蛋白对高血压早期肾损害的作用研究[J].现代生物医学进展英文版,2012,12(24):4685-4687. |
| 探讨尿视黄醇结合蛋白对高血压早期肾损害的作用研究 |
| Explore Urine Retinol Combined with Protein to High Blood PressureEarly Renal Damage Role Research |
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| DOI： |
| 中文关键词: 尿视黄醇结合蛋白 尿N- 乙酰-β-D- 氨基葡萄糖苷酶 尿胱蛋白酶抑制剂C 高血压早期肾损害 |
| 英文关键词: Urinates RBP Urinates NAG Urinates CystatinC Hypertension early time kidney harm |
| 基金项目: |
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| 中文摘要: |
| 目的：探讨尿视黄醇结合蛋白（RBP）、尿N- 乙酰-β-D- 氨基葡萄糖苷酶（NAG）、尿胱蛋白酶抑制剂C（Cystatin C）的测定对
原发性高血压早期肾损害诊断的敏感性及临床意义。方法：选择2011 年4 月～2011 年11 月在新疆自治区人民医院肾病科住院
的原发性高血压患者69 例作为观察组，另设健康体检者30 例为对照组。尿RBP、Cystatin C 测定采用酶联免疫法（ELISA）检测，
尿NAG 测定采用对硝基苯酚（PNP）比色法检测。结果：观察组中尿RBP、NAG、Cystatin C 的测定含量明显高于正常对照组（P＜
0.001）,通过ROC 曲线、诊断试验结果显示：尿RBP 的曲线下面积为0.962，95%可信区间为0.921～0.983，较尿NAG、Cystatin C
更具有敏感性（P＜0.001）。结论：检测尿RBP 有助于高血压肾损害的早期监测，对预防高血压性肾病的发生、发展具有重要的临
床价值。 |
| 英文摘要: |
| Objective: The sensitive index and clinical significance in early renal injury caused by primary hypertension was investigate
by detecting Urine retinol combined with protein(RBP), N-acetyl-β-D-amino grape glycosidase (NAG), urine micro proteinase inhibitor
C (Cystatin C). Methods: 69 patients with primary hypertension were enrolled who were in-patients, dated from April 2011 to
November 2011; 30 subjects of healthy people for the outpatient were selected as control group. The urine RBP and urine Cystatin C
were respectively determined by enzyme linked immunosorbent assay (ELISA). Urine NAG was measured by p-nitrophenol (PNP) colorimetric
assay. Results: In case group urine RBP, NAG and the Cystatin C determination content were higher that in the normal control
group, the differences were statistically significant (P<0.001).Through the ROC curve and diagnostic test, the area under the curve of
Urine RBP were 0.962, the 95% confidence interval were 0.921～0.983(P<0.001). Conclusions: The urine RBP could be helpful in early
detection of hypertensive renel injury, and there was important clinical value in the prevention of hypertensive renel injury. |
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