Article Summary
季宏志许西琳△.基因多态性与慢性阻塞性肺疾病易感性关系研究的新进展[J].现代生物医学进展英文版,2012,12(23):4569-4571.
基因多态性与慢性阻塞性肺疾病易感性关系研究的新进展
Research Advance on Correlation between Polymorphism of Genetic Geneand Susceptibility to Chronic Obstructive Pulmonary Disease
  
DOI:
中文关键词: 慢性阻塞性肺疾病  多态性  遗传易感性
英文关键词: Chronic obstructive pulmonary disease  Polymorphisms  Genetic susceptibility
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Author NameAffiliation
JI Hong-zhi, XU Xi-lin△ 石河子大学医学院第一附属医院呼吸内科 
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中文摘要:
      慢性阻塞性肺疾病(chronic obstructive pulmonary disease,COPD)是一组气流受限为特征的肺部疾病,气流受限不完全可逆, 呈进行性发展。它受遗传因素,环境因素以及遗传- 环境相互作用的影响。目前,虽然其确切的病因及发病机制不甚明了,但是近 年来的研究表明COPD 是一种多基因调控的疾病。本文综述了几个较为重要的遗传基因多态性与COPD 易感性关系的近期研究 进展。
英文摘要:
      Chronic obstructive pulmonary disease (COPD) is a slowly progressing lung disease characterized by irreversible airflow limitation in the lungs. COPD is a complex disease which is influenced by genetic factors, environmental agents, and gene-environmental interactions. At present, although the etiological factor and pathogenesis of COPD are uncertain,in recent years, studies have shown that COPD was a muti-gene regulated disease. This paper summarizes the relation of several important genetic gene polymorphisms and the susceptibility of COPD.
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