| 李翠萍卢美松△.肝素结合表皮生长因子及其在恶性肿瘤中的作用[J].现代生物医学进展英文版,2012,12(23):4566-4568. |
| 肝素结合表皮生长因子及其在恶性肿瘤中的作用 |
| HB-EGF and its Role in Cancer |
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| DOI： |
| 中文关键词: 肝素结合表皮生长因子 肿瘤 CRM197 |
| 英文关键词: Heparin-binding epidermal growthfactor Cancer CRM197 |
| 基金项目: |
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| 中文摘要: |
| 肝素结合表皮生长因子属表皮生长因子超家族成员之一，可促进多种细胞分裂和增殖，参与多个病理生理过程。近年研究
发现肝素结合表皮生长因子可参与肿瘤发生发展的各个环节，在肿瘤化疗耐药中也发挥一定作用，使其成为恶性肿瘤生物学治
疗的靶向因子。其与白喉毒素结合的特性为临床提供了一种新的治疗癌症的途径。继续对HB-EGF 进行深入的研究，并将已获得
的知识与临床治疗结合，将有望产生新的治疗恶性肿瘤的途径及新型的抗肿瘤药物。 |
| 英文摘要: |
| Heparin-binding epidermal growthfactor (HB-EGF), which belongs to the epidermal growthfactor (EGF) family,has
been implicated as a contributer to a variety of physiological and pathological processes. Moreover, HB-EGF has been shown to stimulate
the growth and proliferation of variety of cells .In recent years, HB-EGF has also been found to be implicated in each of the hallmarks
characteristic of neoplastic disease and in the resistance to chemotherapy of tumor making it a targeted factor for biological therapy of
cancer.Its unique identity as a receptor for diphtheria toxin may provide novel avenues for cancer therapeutics.The future challenge will
be to lucubrate HB-EGF and to translate our knowledge of this inimitable molecule into treatments,then we can expected new ways and
new drugs for cancer. |
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