| 曹薇薇晏真明余少培.CD27／CD27L 在肝癌患者血清中的含量及临床意义[J].现代生物医学进展英文版,2012,12(23):4511-4513. |
| CD27／CD27L 在肝癌患者血清中的含量及临床意义 |
| The Clinical Significance of Detection of Serum CD27 and CD27L inHepatocellular Carcinoma |
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| DOI： |
| 中文关键词: 原发性肝癌 CD27 CD27L |
| 英文关键词: Primary liver carcinoma CD27 CD27L |
| 基金项目: |
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| 中文摘要: |
| 目的：探讨原发性肝癌患者外周血中CD27 和CD27L 的含量及其临床意义。方法：采用ELISA 法检测38 例肝癌患者和40
例健康查体者外周血中CD27 及CD27L 蛋白的含量，并分析两者与病理类型和临床分期的关系。结果：与健康查体组相比，肝癌
患者外周血中CD27 蛋白含量未检测到明显变化（t=1.760, P=0.082），但CD27L 蛋白含量显著升高（t=39.982, P<0.001）。Spearman
秩相关分析表明CD27 和CD27L 之间无显著相关性（rs =0.305, P=0.084）。CD27 在不同病理类型和不同病理分期的肝癌患者血
清中的含量无统计学差异（P>0.05）；CD27L 蛋白含量在III 期和发生淋巴结转移的患者中显著升高（P<0.05）。结论：CD27/CD27L
通路与肝癌的恶性进展和淋巴结转移有密切关系。 |
| 英文摘要: |
| Objective: To investigate the serum concentration and the clinical pathological significance of CD27 and CD27L
protein in hepatocellular carcinoma (HCC). Methods: The serum concentration of CD27 and CD27L in 38 cases of HCC and 40 cases of
healthy examinations (normal control) were detected by ELISA method. The relationships between the expression of the two proteins and
the clinical pathological athological types and stagings were analyzed by statistical methods. Results: The serum concentration of CD27
in HCC patients was similar to normal control (t=1.760, P=0.082), but the level of CD27L in HCC patients was higher than in normal
control (t=39.982, P<0.001). Spearman correlation showed no significant relationship between expressions of CD27 and CD27L (rs =0.
305, P=0.084). In patients with HCC, no statistics difference of CD27 level existed in all pathological types and stagings (P>0.05), but the
concentration of CD27L was obviously increased in stage III and lymphatic metastasis of patients (P<0.05). Conclusion: The pathway of
CD27/CD27L has close relationship with malignant progression and lymphatic metastasis of HCC. |
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