| 孔德胜赵红丽董敏孙国勋施婺丹洪珞珈△.雷利度胺治疗难治复发急性粒细胞白血病临床观察[J].现代生物医学进展英文版,2012,12(23):4493-4495. |
| 雷利度胺治疗难治复发急性粒细胞白血病临床观察 |
| Clinical Observation of Lenalidomide Treat Relapsed or Refractory AcuteMyeloblastic Leukemia |
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| DOI： |
| 中文关键词: 雷利度胺；难治复发 急性粒细胞白血病；治疗 |
| 英文关键词: Lenalidomide Relapsed or Refractory Acute Myeloblastic Leukemia Treat |
| 基金项目:黑龙江省留学人员归国基金（LC08C24） |
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| 中文摘要: |
| 目的：观察雷利度胺治疗难治复发急性粒细胞白血病的疗效及不良反应。方法：给予雷利度胺单药治疗，雷利度胺50mg/d，
口服给药，连续给药21 天，28 天为一个疗程。结果：应用雷利度胺4（2～6）个疗程，5 例有效，2 例获得完全缓解，2 例部分缓解，
1 例因疾病迅速进展死亡退出试验。不良反应主要为疲乏4 例，中性粒细胞减少性发热3 例，中粒细胞减少4 例，血小板减少1
例，贫血1 例。结论：应用雷利度胺治疗难治复发白血病有效，不良反应轻微且易于耐受。 |
| 英文摘要: |
| Objective: To observe toxicities and efficacy in patients relapsed or refractory acute myeloblastic leukemia with
lenalidomide. Methods: Lenalidomide was given orally at doses of 50mg daily on days 1 through 21 of 28-day cycles. Results: Six
Patients were given a median of four prior therapies (range, two to six therapies), five patients with AML responded. Two of 6 patients
achieved complete remission (CR), two of 6 patients achieved partial remission (PR), one of 6 patients achieved Peripheral blood
improvement,One patient had disease progression death. Toxicities of lenalidomide were Fatigue (4/6), febrile neutropenia (3/6),
neutropenia (4/6), thrombocytopenia(1/6), anemia(1/6). Conclusions: Lenalidomide has significant activity in relapsed or refractory acute
myeloblastic leukemia patients and the toxicities was active with relatively low toxicity in patients with relapsed/refractory AML. |
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