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目的：探讨叶酸对心脑血管疾病二级预防的效果。方法：326 例恢复期心脑血管疾病患者以自愿的原则分为实验组（n=201）和对照组（n=125），对照组针对病因应用常规药物，实验组在针对病因常规用药的基础上应用叶酸，随访三年，所有患者均在实验前和半年后测一次血清同型半胱氨酸含量，同时记录对比两组心脑血管不良事件的发生率。结果：323 例纳入统计，实验组和对照组在入选时同型半胱氨酸含量无差异（P＞0.05），半年后实验组血清同型半胱氨酸含量显著低于对照组（P<0.05）；心绞痛、心力衰竭、血栓形成等发生率差异均具有统计学意义（均为P<0.05），而在心肌梗死、脑梗死和病死率等方面差异没有统计学意义（P＞ 0.05）。结论：叶酸在心脑血管疾病二级预防中可以降低心绞痛发生率、心力衰竭、血栓形成的发生率，对心肌梗死、脑梗死和病死率没有明显的影响。

英文摘要:

Objective: To explore the Secondary prevention effectiveness of folic acid on Cardiovascular and cerebrovascular diseases. Methods: There are 326 patients with Cardiovascular and cerebrovascular diseases were divided into the experimertal group (n=201) and the control group (n=125) by voluntary principle,the experimertal group treated with common treatment and folic acid and the control group only treated with common treatment. follow-up visit for 3 year, serum homocysteine (Hcy) of experimertal group and the control group was Detected before and after six months ' test. cardiovascular and cerebrovascular events were recorded and compared in the two groups simultaneously. Results: 323 cases adopted and statisticed , there was no statistical significance of serum homocysteine(Hcy) level(P>0.05)between the two groups before test, there was significant difference (P < 0.05) between the two groups in serum homocysteine (Hcy) level. The incidence of angina, heart failure and thrombosis in the two groups had significant differences (p <0.05). The incidence of myocardial infarction, cerebral infarctio and mortality in the two groups had no statistical significance(P>0.05). Conclusion: Folic acid can reduce the incidence of angina, heart failure and thrombosis, It had no effect on incidence of myocardial infarction, cerebral infarctio and mortality in Secondary prevention of Cardiovascular and cerebrovascular diseases.

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