| 姚寒曦△ 徐汉文李华珍.四种口腔修复材料对细胞的毒性分析[J].现代生物医学进展英文版,2012,12(23):4473-4475. |
| 四种口腔修复材料对细胞的毒性分析 |
| Toxicity Analysis of Four Non-noble Metal Oral Cavity Repair Materialson Oral Epithelium Cell |
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| DOI： |
| 中文关键词: 非贵金属材料 毒性 口腔上皮细胞 |
| 英文关键词: Non-noble Metal Materials Toxicity Oral Epithelium Cell |
| 基金项目:上海中医药大学专项科研基金 |
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| 中文摘要: |
| 目的：研究纯钛、钛合金、钴铬合金和镍铬合金四种非贵金属口腔修复材料对L-929 成纤维细胞的毒性作用。方法：应用口
腔修复材料制备材料浸提液处理培养L-929 细胞，采用AnnexinV-FITC 试剂盒比较细胞凋亡水平改变,采用Western blot 检测细
胞凋亡相关基因的表达。结果：纯钛与钛合金诱导L-929 细胞凋亡的水平与对照组没有统计学差异（P >0.05）；钴铬合金和镍铬合
金材料浸提液可引起L-929 细胞凋亡增加（P<0.05）。结论：纯钛与钛合金材料对口腔黏膜细胞的毒性作用相较钴铬合金和镍铬
合金材料低，更具安全性。 |
| 英文摘要: |
| Objective: To compare the toxicity on oral epithelium cell among four non-noble oral repair materials including pure
Ti, Ti alloy, Co-Cr alloy and Ni-Cr alloy materials. Methods: We used cell culture, AnnexinV-FITC kit and Western blot to evaluate the
cell apoptotic levels induced by different materials. Results: Ti and Ti alloy material could not induce detectable apoptosis in oral
epithelium cell line L-929 (P <0.05), while Co-Cr alloy and Ni-Cr alloy could cause increased cell apoptosis compared with controls (P <
0.05). Conclusions: Ti and Ti alloy materials cause less toxicity on oral epithelium cells than Co-Cr alloy and Ni-Cr alloy materials,
which proved to be safer in clincial use. |
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