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目的：探讨C 反应蛋白(CRP)检测在足月胎膜早破(PROM)孕妇中的临床意义。方法：选取足月胎膜早破(PROM)孕妇50 例为实验组，并根据破膜时间将足月破膜孕妇分为3 个亚组；并选取同期住院的正常孕妇30 例为对照，采用高敏CRP 试剂盒，测定不同组别孕妇中CRP 水平。结果：入院时，胎膜早破各亚组中CRP 水平明显高于对照组，具有显著统计学意义(P<0.05)；同时随着破膜时间的增加，各亚组中的CRP 水平及WBC 计数也逐渐升高，且3 个亚组之间也分别存在统计学差异(P<0.05)。在应用抗生素 3d 后，CRP 出现显著下降，与正常组相比未见明显差异(P>0.05)；WBC 计数在应用抗生素后的3d 时间出现下降，但与入院前相比未见明显统计学差异。结论：CRP 检测在判断孕妇胎膜早破、指导临床用药方面具有较高的临床价值，可作为常规检查项目。

英文摘要:

Objective: To investigate the clinical significance of C-reactive protein (CRP) detection in pregnant women with premature rupture of membranes (PROM) of full-term pregnancy. Methods: Compared with control group concluding 30 cases of normal pregnant women, there are 50 cases with premature rupture of membranes (PROM) of full-term pregnancy in the experiment group which was divided into 3 subgroups according to the time in remature rupture of membranes, and high sensitivity CRP kit was to determine the CRP level in the different groups of pregnant women. Results: Compared with the control group, the CRP levels in the patients with PROM were higher significantly in the subgroups (P<0.05) at the time of admission. After the application of antibiotics for 3 days, CRP levels decreased significantly, which shows no significant difference (P>0.05) compared with the control group; and WBC count also declined in the time of 3d after antibiotics using, but there were no significant statistical difference compared with time of admission. Conclusion: CRP testing can be as a routine examination in determining the pregnant women with PROM, shows the high clinical value.

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