| 王显悦△ 毕生辉王晓武张卫达梅鲁刚梁爱琼徐宇.左西孟旦治疗心脏术后左心室收缩功能低下[J].现代生物医学进展英文版,2012,12(23):4464-4466. |
| 左西孟旦治疗心脏术后左心室收缩功能低下 |
| Treatment of Levosimendan in Patients with Left Ventricular SystolicDysfunction Postcardiotomy |
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| DOI： |
| 中文关键词: 左西孟旦 心脏术后 左心室射血分数 |
| 英文关键词: Levosimendan Postcardiotomy Left ventricular ejection fraction |
| 基金项目:广州市科技计划重点项目（2011J4100021） |
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| 中文摘要: |
| 目的：明确左西孟旦治疗心脏术后左心室收缩功能低下的效果。方法：随即抽取2009 年6 月至今手术治疗后左室射血分数
小于35％的患者，分为治疗组和对照组，各25 例，给与不同治疗方案。比较两组患者治疗后效果；呼吸状况和全身状况；再次气管
插管例数和监护室滞留时间；治疗后左心室射血分数（LVEF）、小轴短缩率（LVFS）。结果：治疗组和对照组分别有3 例和5 例因心
力衰竭死亡。两组患者治疗后再次气管插管例数无统计学差异。与对照组比较，治疗组患者监护室滞留时间短、呼吸状况和全身
状况较好(P <0.05)，LVEF 和LVFS 较高有统计学意义(P <0.05)。结论：左西孟旦治疗心脏术后左心室收缩功能低下安全有效，缓
解症状明显。 |
| 英文摘要: |
| Objective：To identify the effect of Levosimendan in patients with left ventricle systolic dysfunction postcardiotomy.
Methods: Patients with LVEF below 35% postcardiotomy were randomly grouped as treatment group (25cases) and control group
(25cases) since May 2009. Different treatment methods were used for the two groups. The clinical records from two groups were
compared in terms of treatment effect ,condition of respiratory and whole body ,ICU time ,frequency of re-intubation and left ventricular
ejection fraction (LVEF) and left ventricular short-axis fractional shortening (LVFS). Results: Three cases in treatment group and five
cases in control group died of heart failure. There was no statistical difference between the two groups in frequency of re-intubation.
Compared with control group, treatment group had shorter time of ICU stay (P < 0.05), and better condition of respiratory and whole
body ( P < 0. 05). Treatment group had a significantly higher LVEF and LVFS than control group. (P < 0.05) Conclusion: The
applications of Levosimendan in patients with left ventricle systolic dysfunction postcardiotomy are safe and effective, and it can relieve
symptom obviously. |
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