| 王秀玲卢美松△ 李翠萍孙雪竹常桂荣吕冠军.YKL-40 和NF-κ B 在子宫内膜异位症中的表达及相关性研究[J].现代生物医学进展英文版,2012,12(23):4454-4457. |
| YKL-40 和NF-κ B 在子宫内膜异位症中的表达及相关性研究 |
| Expressions and Correlation of YKL-40 and Nuclear Factor- kappaBin Endometriosis |
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| DOI： |
| 中文关键词: 子宫内膜异位症 人类软骨蛋白39（YKL-40） NF-κ B 免疫组织化学 |
| 英文关键词: Endometriosis Human cartilage glycoprotein-39(YKL-40) Nuclear factor-kappaB Immunohistochemistry |
| 基金项目: |
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| 中文摘要: |
| 目的：通过检测人类软骨蛋白39（YKL-40）和核转录因子KappaB(NF-κ B)在子宫内膜异位症组织中的表达，探讨二者与子
宫内膜异位症的关系及二者的相关性。方法：用免疫组化二步法检测40 例子宫内膜异位症（EMS）患者的异位内膜和在位内膜及
40 例子宫肌瘤患者子宫内膜（对照组）YKL-40 和NF-κ B 的表达，并对检测结果进行统计学分析。结果：YKL-40、NF-κ B 在子宫
内膜异位症患者的异位和在位内膜及对照组内膜中的表达率分别为67.5%、62.5%、35%及88.5%、57.5%、32.5%，差异有统计学意
义（P<0.01）；在不同月经周期YKL-40 表达无统计学意义；在位内膜和正常内膜NF-κ B 的表达分泌期高于增殖期，差异有统计学
意义（P<0.05）；YKL-40 和NF-κ B 在三种内膜中的表达具有正相关性，相关系数分别是0.305，0.267 和0.457 （P<0.01）。结论：
YKL-40 和NF-κ B 在EMS 发生发展中起重要的作用。 |
| 英文摘要: |
| Objective: To investigate the expressions of Human cartilage glycoprotein-39 (YKL-40) and Nuclear factor-kappaB in
endometriosis, and to evaluate the relationship between the YKL-40 and NF-κ B expressions. Methods: Immunohistochemistry was used
to examine the YKL-40 and NF- κ B protein expressions in eutopic (n=40) and ectopic (n=40) endometrium of Ems, as well as
endometrium of hystromyoma (n=40). The results were analyzed statistically. Results: The positive rate of YKL-40 and NF- κ B
expressions in ectopic, eutopic and normal endometrium respectively were 67.5%, 62.5%, 35% and 88.5%, 57.5%, 32.5%(P<0.01); NF-κ
B expression was higher in secretory phase than that in proliferative phase in the eutopic and normal endometrium (P<0.05), but YKL-40
was not correlated with the phase of menstrual cycle; Furthemore, the expression of YKL-40 and NF- κ B protein was positively
correlated in these three medometrial tissue (rs=0.305, 0.247 and 0.467, P<0.01). Conclusion: The over expression of YKL-40 and NF-κ
B may play an important role in the pathogenesis of endometriosis. |
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