| 邱少敏彭鹏△ 宋玉华徐月娟.肝癌患者血清趋化因子配体18 的检测及其意义[J].现代生物医学进展英文版,2012,12(22):4275-4276. |
| 肝癌患者血清趋化因子配体18 的检测及其意义 |
| Role of Chemokine CC-motif Ligand 18(CCL18)in Liver Cancer Metastasia |
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| DOI： |
| 中文关键词: 趋化因子配体18(CLL18) 肝癌 转移 |
| 英文关键词: CCL18 Liver cancer Metastasis |
| 基金项目:国家自然科学基金项目（30770823） |
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| 中文摘要: |
| 目的：为研究趋化因子配体18(CLL18)在肝癌患者外周血中的表达,探讨其在肝癌癌浸润、转移中的作用。方法：选取
2008.1-2010.12 年我科的原发性肝癌患者，均经病理或临床确诊，年龄18～70 岁，如曾实施化疗，须化疗结束1 个月以上而有实
体瘤者或手术未能切除者。有转移组50 例，其中男性25 例，女性25 例。无转移组50 例，其中男性25 例，女性25 例。对照组50
例，为正常健康人群50 例，其中男性25 例，女性25 例。以ELISA 法检测外周血CCL18 含量。结果：有转移组患者外周血中
CCL18 浓度为(137. 63±35. 56) pg/mL显著高于健康人（47.53±17.22)pg/mL(P<0.05)。无转移组患者外周血中CCL18 浓度为(260.
27±73.41) pg/mL 显著高于健康人(P<0.05)。结论：肝癌患者血浆中的CCL18 水平显著高于正常人，并能反映肝癌的进展，有助于
对肝癌患者进行预后判断，具有一定的临床价值。 |
| 英文摘要: |
| Objective: To investigate the possible role of CCL18 in migration and metastasis of liver cancer by studying it's
expression in serum. Methods: The levels of serum CCL18 in 100 patients with liver cancer and 50 control groups were analyzed by
ELISA method. Results: Showed that the levels of serum CCL18 in 100 patients with liver cancer (with metastatic: 137. 63±35. 56
pg/mL, without metastatic: 260.27±73.41 pg/mL) were significantly increased. Compared with control groups (P<0.05). Conclusions: It
is deduced that CLL18 over-expression might play an important role in the invasion of liver cancer. |
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