| 禄颖1 苏晶2 余轶群3 郑丰杰1 柴新楼1 徐雅1.北京中医药大学基础医学院[J].现代生物医学进展英文版,2012,12(22):4241-4244. |
| 北京中医药大学基础医学院 |
| Observation of the Effect of Gengxiaoyao Granule on PerimenopausalDepression Model Rats Behavior and Learning |
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| DOI： |
| 中文关键词: 更年期抑郁症 行为学 学习记忆能力 更逍遥冲剂 |
| 英文关键词: Perimenopausal Depression Behavior science Ability of learning and memory Gengxiaoyao Granule |
| 基金项目:香港大学专业进修学院科研经费资助项目- 更逍遥冲剂治疗更年期抑郁症的临床与实验研究 |
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| 中文摘要: |
| 目的：通过对更年期抑郁症模型大鼠行为学以及学习记忆的观察，探讨中药复方更逍遥冲剂的作用机制。方法：SD 雌性大
鼠40 只，随机分为假手术组、更年期抑郁症模型组、中药中剂量组、中药大剂量组和西药对照组，观察开野实验中大鼠活动度、强
迫游泳中大鼠的不动时间、以及通道式水迷宫检测大鼠学习记忆能力。结果：模型大鼠经过21d 治疗后，开野实验水平积分、垂直
积分明显增加，强迫游泳不动时间缩短，水迷宫实验游出时间缩短，错误次数减少。结论：更逍遥冲剂能够明显的改善更年期抑郁
症大鼠的行为学评分，并具有改善其学习记忆能力的作用。 |
| 英文摘要: |
| Objective: To investigate the Gengxiaoyao Granule's mechanism of action, through the observation of perimenopausal
depression model rats behavior and learning. Methods: 40 SD female rats, were randomly divided into sham operation group, model group,
middle dose Chinese medicine group, high dose Chinese medicine group and Western medicine group; we observed rat activity in the
open field test, the immobility time on forced swimming, and memory ability through channel type water maze. Results: Model of rat
after treatment with 21d, level integration, vertical integration in the open field tests was significantly increased, immobility time of
forced swimming was reduced; in channel type water maze experiment, travel time were significantly shortened, and the error time was
reduced. Conclusion: Gengxiaoyao granule can obviously improve the behavior scores of perimenopausal depression rats, and has
improved the ability of learning and memory. |
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