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目的：探讨术前血清促甲状腺激素（TSH）水平与甲状腺结节良恶性的关系。方法：回顾性分析了1499 例甲状腺结节手术切除患者术前血清TSH、甲状腺B 超，手术记录、术后病理诊断报告。根据术后病理报告判定甲状腺结节良恶性，分析术前血清TSH 水平在甲状腺良恶性结节中的不同分布。结果：分化型甲状腺癌（DTC）患者术前血清TSH 水平明显高于甲状腺良性结节组（2.179±2.017vs1.259±0.884 μIU/mL），P<0.001；在DTC 患者中，有淋巴结转移较无淋巴结转移、TNM 分期III、IV 期较I、II 期以及肿瘤直径≥1cm 较＜1cm 的患者术前血清TSH 明显升高(均P<0.001)。结论：术前血清TSH 水平是预测甲状腺结节良恶性的重要指标。

英文摘要:

Objective: To investigate the relationship between preoperative serum thyroid stimulating hormone (TSH) levels and the benign or malignant thyroid nodules. Methods: The serum TSH level, thyroid B-Doppler ultrasound reports, surgical records, pathological diagnosis reports of 1499 thyroid nodules selected patients were retrospectively analyzed. According to pathology reports to determine the benign or malignant thyroid nodules, the different distribution between benign and malignant thyroidnodules in preoperative serum TSH levels was analyzed. Results: The preoperative serum TSH levels in patients of differentiated thyroid carcinoma (DTC) were significantly higher than those in benign thyroid nodules group (2.179 ± 2.017vs1.259 ± 0.884 μIU / ml), P <0.001; In DTC patients, lymph node metastasis than those without lymph node metastasis, TNM stage III, IV longer than I, II stage, and tumor diameter ≥1 cm more <1 cm in patients with preoperative serum TSH was significantly higher (all P <0.001). Conclusion: Preoperative serum TSH levels is an important indicator to whether thyroid nodules benign or malignant.

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