| 张健王磊赵智宏王巨刘鑫远禹亮△.Pokemon、P14ARF 蛋白在食管鳞状细胞癌中的表达及临床意义[J].现代生物医学进展英文版,2012,12(21):4050-4053. |
| Pokemon、P14ARF 蛋白在食管鳞状细胞癌中的表达及临床意义 |
| Expression and Clinical Significance of Pokemon and P14ARF inEsophageal Squamous Cell Cancer |
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| DOI： |
| 中文关键词: 鳞癌 食管肿瘤 Pokemon P14ARF 预后 |
| 英文关键词: Squamous cell cacinoma Esophageal neoplasm Pokemon P14ARF Prognosis |
| 基金项目:黑龙江省卫生厅科研课题（2010-039）；哈尔滨医科大学第一医院科研基金（2009L05） |
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| 中文摘要: |
| 目的：探讨食管鳞癌（esophageal squamous cell cacinoma，ESCC）组织中Pokemon 和P14ARF 表达的关系及其对ESCC 临床
病理特征和预后的判定价值。方法：应用SP 免疫组织化学方法检测Pokemon 和P14ARF 二种蛋白在96 例ESCC 组织及20 例癌
旁正常组织中的表达，分析它们与ESCC 病理学特征的关系，以及Pokemon 和P14ARF 的相关性，并结合随访资料观察上述蛋白
表达对ESCC 长期预后的影响。结果：癌旁正常组织中未见Pokemon 蛋白表达，P14ARF 蛋白阳性表达率为90.0 %；在ESCC 组
织中Pokemon 和P14ARF 阳性表达率分别为75.0 %和30.2 %。Pokemon 表达与P14ARF 表达呈负相关（r = -0.458，P=0.000)。
Pokemon 和P14ARF 的表达与TNM 分期和淋巴结转移相关（P＜0.05）。Pokemon 表达阳性组的5 年生存率分别为20.8 %，显著
低于阴性组（P=0.004）；P14ARF 表达阳性组的5 年生存率为41.4 %，显著高于阴性组（P=0.011）。结论：Pokemon 蛋白的高表达和
P14ARF 蛋白低表达可能与ESCC 的发生、发展关系密切，它们对于ESCC 预后评估有一定的临床意义。 |
| 英文摘要: |
| Objective: To investigate the correlation of the expression of Pokemon and P14ARF in esophageal squamous cell cacinoma
(ESCC)tissues, and their values for determining the clinicopathological characteristics and prognosis of ESCC. Methods: Immuno
histochemical SP staining was used to detect the expressions of pokemon and P14ARF proteins in 96 ESCC tumor tissues and 20 adjacent
normal tissues. Their relationship with the pathological characteristics of ESCC was analyzed.The correlation of abnormal expressions of
pokemon and P14ARF was analyzed.The effects of the expressions of the two proteins on the long-term prognosis of ESCC patients were
observed based on the follow-up data. Results: In normal tissues there was no Pokemon expression but the positive rate of P14ARF expression
was 90.0 %. In ESCC tissues, the positive rate of Pokemon and P14ARF protein were 75 % and 30.2 %,respectively. The expression
of Pokemon had negative correlation with expression of P14ARF（r=-0.458，P=0.000). The expression of Pokemon and P14ARF
were associated with TNM staging and lymph node metastasis(P<0.05). In Pokemon positive patients,the five-year survival rate was 20.8
%, which was significantly lower than that in Pokemon negative patients (P=0.004). In contrast,the five-year survival rate was 41.4 % in
patients with positive expression of P14ARF, which was significantly higher than that in patients with negative expression of P14ARF
(P=0.011). Conclusion: The over expression of Pokemon and the less expression of P14ARF maybe play important roles in the development
of ESCC. Pokemon and P14ARF have a certain clinical significance for evaluating the prognosis of ESCC patients. |
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