| 王丽雅廖学娟郑晓辉龙洁△.Wnt 信号通路与骨髓间充质干细胞成骨之间的关系[J].现代生物医学进展英文版,2012,12(20):3981-3984. |
| Wnt 信号通路与骨髓间充质干细胞成骨之间的关系 |
| The Relationship between Osteogenic Differentiation of BoneMarrow Mesenchymal Stem Cell and Wnt Signal Pathways |
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| DOI： |
| 中文关键词: 骨髓间充质干细胞 Wnt 信号通路 骨向分化 |
| 英文关键词: Bone marrow mesenchymal stem cells Wnt signal pathways Osteogenic differentiation |
| 基金项目:四川省科技支撑计划（2010GZ0225，2009SZ0139） |
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| 中文摘要: |
| Wnt 信号通路是由Wnts 诱发的一系列相互作用的分子组成。Wnt 信号对骨髓间充质干细胞的影响在所有研究中均证实有
明显作用，其可调节干细胞增殖、分化及凋亡。研究表明，抑制Wnt 信号通路转导可使成骨细胞分化进程受阻，从而抑制骨形成；
若诱导Wnt 家族成员表达则可使成骨细胞特异性基因表达增加，促进骨形成。本文就Wnt 信号通路的作用过程及其与骨髓间充
质干细胞成骨诱导的关系做一综述。 |
| 英文摘要: |
| The component of Wnt signal pathways is some interactional molecules induced by Wnts. All previous researches
have indicated that Wnts have apparently effects on the biological behavior of bone marrow mesenchymal stem cell (BMSCs). Wnts
could regulate cell growth, differentiation and apoptosis. The inhibition of Wnt signal pathways will lead to the osteogenic process delay,
and the bone formation will be blocked. On the other hand , if we induce the opening of Wnts pathway , the specific osteogenic genes of
osteoblast will show high expression and the bone formation will be promoted. A key remaining question is how Wnt signal pathways
work during the osteogenic process of BMSCs. In this report, we reviewed the previous relative studies which investigated the
Wnt-receptor binding system and the downstream intracellular response , and the relationship between osteogenic differentiation of bone
marrow mesenchymal stem cell and Wnt Signal Pathways were also described in this report. |
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