| 于俊民鞠礼王慧冬万晓京杨敬生.中药促缺血心肌血管新生机制研究进展[J].现代生物医学进展英文版,2012,12(20):3978-3980. |
| 中药促缺血心肌血管新生机制研究进展 |
| Progress of Mechanisms in Traditional Chinese Medicineon Angiogenesis of Ischemic Myocardium* |
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| DOI： |
| 中文关键词: 中药 心肌梗死 血管新生 |
| 英文关键词: Chinese Medicine Myocardium Infarction Angiogenesis |
| 基金项目:黑龙江省中医药科研资助项目（ZHY10-Z94） |
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| 中文摘要: |
| 中药在缺血性心脏病的治疗方面具有重要作用，能够缓解症状并改善预后，促血管新生可能是其发挥作用的机制之一。已
证实通过促进血管新生，可使心肌梗死面积缩小，减少细胞坏死和凋亡，改善心功能等，但其机制尚需进一步明确。目前中医药在
促进梗死心肌血管新生研究方面已经取得了一定的成果，研究发现，大量中药单体、方剂及中成药具有促进血管新生作用。随着
对中药促血管新生研究的不断深入，其机制的研究亦愈趋广泛，已深入到细胞及分子水平：涉及骨髓干细胞，促进血管生长的因
子及其受体（血管内皮细胞生长因子、碱性成纤维细胞生长因子、胰岛素样生长因子等），抑制血管生长的因子（血管抑素、内皮抑
素）及Akt/NOS/NO 等通路。本文就相关研究回顾中药对缺血心肌血管新生影响并对机制进行探讨。 |
| 英文摘要: |
| Traditional Chinese Medicine (TCM) has important effect in the treatment of ischemic heart disease on the relief of
symptoms and improvement of prognosis. One possible underlying mechanism is TCM can promote angiogenesis.It is clear that angiogenesis
can reduce area of infarcted myocardium, decrease cytoclasis and apoptosis, and improve heart function etc. But its mechanisms
need further confirmed. Some achievements have been achieved about the TCM for promoting angiogenesis in infarcted myocardium. It
was found that many Chinese herbal monomer, prescription and patent medicine can promote angiogenesis. With further researches, the
mechanisms become more extensive and deeper into cellular and molecule levels: such as marrow stem cells, angiogenesis promotion
factors and their receptors (vascular endothelial cell growth factor, basic fibroblast growth factor, insulin-like growth factor, etc), angiogenesis
inhibition factors (angiostatin, endostatin) and pathways (Akt/NOS/NO, etc).This article is to review the mechanisms and effects of
TCM on angiogenesis of ischemic myocardium based on available publications. |
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